Hepatitis B Virus X Protein: Molecular Functions and Its Role in Virus Life Cycle and Pathogenesis

被引：128

作者：

Benhenda, Shirine ^{[1
]}

Cougot, Delphine ^{[1
]}

Buendia, Marie-Annick ^{[1
]}

Neuveut, Christine ^{[1
]}

机构：

[1] Inst Pasteur, INSERM, Unite Oncogenese & Virol Mol, U579, F-75724 Paris 15, France

来源：

ADVANCES IN CANCER RESEARCH, VOL 103 | 2009年 / 103卷

关键词：

NF-KAPPA-B; TATA-BINDING PROTEIN; HUMAN LIVER-CELLS; HUMAN HEPATOCELLULAR-CARCINOMA; NUCLEOTIDE EXCISION-REPAIR; PRIMARY MOUSE HEPATOCYTES; GENE-EXPRESSION PROFILES; PRIMARY RAT HEPATOCYTES; NECROSIS-FACTOR-ALPHA; CELLULAR-DNA-REPAIR;

D O I：

10.1016/S0065-230X(09)03004-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the existence of effective vaccines, HBV infection remains a major health problem with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a major risk factor for the development of hepatocellular carcinoma (HCC). There is a strong need to develop new and efficient treatments against chronic infection and HCC. It is therefore important to understand HBV replication and persistence as well as the role of HBV in liver carcinogenesis. This chapter focuses on the regulatory protein HBx which is thought to play a central role in HBV regulation and pathogenesis. HBx has been shown to modulate a myriad of viral and cellular functions, yet its role in virus replication and pathogenesis in infected individuals remains far from being completely understood. (C) 2009 Elsevier Inc.

引用

页码：75 / +

页数：36

共 235 条

[91] Src kinases involved in hepatitis B virus replication [J].

Klein, NP ;

Bouchard, MJ ;

Wang, LH ;

Kobarg, C ;

Schneider, RJ .

EMBO JOURNAL, 1999, 18 (18) :5019-5027

[92] Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras [J].

Klein, NP ;

Schneider, RJ .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (11) :6427-6436

[93] HIGH-LEVEL EXPRESSION OF HEPATITIS-B VIRUS HBX GENE AND HEPATOCARCINOGENESIS IN TRANSGENIC MICE [J].

KOIKE, K ;

MORIYA, K ;

IINO, S ;

YOTSUYANAGI, H ;

ENDO, Y ;

MIYAMURA, T ;

KUROKAWA, K .

HEPATOLOGY, 1994, 19 (04) :810-819

[94] INDUCTION OF CELL-CYCLE PROGRESSION BY HEPATITIS-B VIRUS HBX GENE-EXPRESSION IN QUIESCENT MOUSE FIBROBLASTS [J].

KOIKE, K ;

MORIYA, K ;

YOTSUYANAGI, H ;

LINO, S ;

KUROKAWA, K .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :44-49

[95] Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies [J].

Koike, K .

JOURNAL OF GASTROENTEROLOGY, 2002, 37 (Suppl 13) :55-64

[96] Compensatory apoptosis in preneoplastic liver of a transgenic mouse model for viral hepatocarcinogenesis [J].

Koike, K ;

Moriya, K ;

Yotsuyanagi, H ;

Shintani, Y ;

Fujie, H ;

Tsutsumi, T ;

Kimura, S .

CANCER LETTERS, 1998, 134 (02) :181-186

[97] Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 [J].

Kong, HJ ;

Park, MJ ;

Hong, SH ;

Yu, HJ ;

Lee, YC ;

Choi, YH ;

Cheong, JH .

HEPATOLOGY, 2003, 38 (05) :1258-1266

[98]

KUMAR V, 2004, STRUCTURE FUNCTION R, V166

[99] The hepatitis B virus X protein up-regulates tumor necrosis factor α gene expression in hepatocytes [J].

Lara-Pezzi, E ;

Majano, PL ;

Gómez-Gonzalo, M ;

Garcíia-Monzón, C ;

Moreno-Otero, R ;

Levrero, M ;

López-Cabrera, M .

HEPATOLOGY, 1998, 28 (04) :1013-1021

[100] The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner [J].

Lara-Pezzi, E ;

Roche, S ;

Andrisani, OM ;

Sánchez-Madrid, F ;

López-Cabrera, M .

ONCOGENE, 2001, 20 (26) :3323-3331

← 5 6 7 8 9 10 11 12 13 14 →