TreeDet: a web server to explore sequence space

被引：21

作者：

Carro, Angel

Tress, Michael

de Juan, David

Pazos, Florencio

Lopez-Romero, Pedro

del Sol, Antonio

Valencia, Alfonso

Rojas, Ana M.

机构：

[1] CNB CSIC, Prot Design Grp, Madrid 28049, Spain

[2] CNIC, Madrid, Spain

[3] Fujirebio Inc, Bioinformat Res Project, Tokyo, Japan

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷

关键词：

D O I：

10.1093/nar/gkl203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TreeDet (Tree Determinant) Server is the first release of a system designed to integrate results from methods that predict functional sites in protein families. These methods take into account the relation between sequence conservation and evolutionary importance. TreeDet fully analyses the space of protein sequences in either user-uploaded or automatically generated multiple sequence alignments. The methods implemented in the server represent three main classes of methods for the detection of family-dependent conserved positions, a tree-based method, a correlation based method and a method that employs a principal component analyses coupled to a cluster algorithm. An additional method is provided to highlight the reliability of the position in the alignments. The server is available at http:// www.pdg.cnb.uam.es/servers/treedet.

引用

收藏

页码：W110 / W115

页数：6

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