Neural correlates of delayed episodic memory in patients with mild cognitive impairment-A FDG PET study

被引：14

作者：

Schoenknechtab, Oskar Dieter Peter ^{[1
,2
]}

Hunt, Aoife ^{[2
]}

Toro, Pablo ^{[2
]}

Henze, Marcus ^{[3
,4
]}

Haberkorn, Uwe ^{[3
,4
]}

Schroeder, Johannes ^{[2
]}

机构：

[1] Univ Hosp Leipzig, Dept Psychiat & Psychotherapy, D-04103 Leipzig, Germany

[2] Heidelberg Univ, Sect Geriatr Psychiatry, D-69115 Heidelberg, Germany

[3] Heidelberg Univ, Clin Cooperat Unit Nucl Med, German Canc Res Ctr DKFZ Heidelberg, D-69120 Heidelberg, Germany

[4] Heidelberg Univ, Dept Nucl Med, D-69120 Heidelberg, Germany

来源：

NEUROSCIENCE LETTERS | 2009年 / 467卷 / 02期

关键词：

Mild cognitive impairment; Episodic memory; Neural correlates; FDG PET; ALZHEIMERS-DISEASE; GLUCOSE-METABOLISM; HYPOMETABOLISM; PERFORMANCE; DEMENTIA; ASSOCIATION; PREDICTION; CONVERSION; DIAGNOSIS; ATROPHY;

D O I：

10.1016/j.neulet.2009.10.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mild cognitive impairment (MCI) is characterized by cognitive deficits which do not yet reach the threshold of dementia but represent a putative preclinical state of Alzheimer's disease(AD). Little is known about the neural correlates of delayed episodic memory which is among the earliest signs of cognitive decline in patients at risk of developing AD. We performed resting state positron emission tomography (PET) with (18)Fluorodeoxyglucose (FDG) in patients with MCI, and hypothesized a correlation between delayed episodic memory performance and frontal glucose metabolism since the latter is relatively spared in the preclinical phase of the disease. 43 patients (age: 69.7 +/- 7.9 years; 24 male, 19 female) with MCI were investigated by FDG PET. Significant positive correlations with delayed episodic memory performance were calculated by statistical parametric mapping. To our knowledge the present study is the first to demonstrate by FDG PET the neural correlates of delayed episodic memory in patients with MCI. Our study revealed a pattern of cerebral glucose metabolism including bifrontal regions which may contribute to the delayed episodic memory performance of patients with MCI. Since not all patients with MCI will further deteriorate, AD specific mechanism may not be concluded from the present study but warrant longitudinal investigations. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：100 / 104

页数：5

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