Multidrug resistance in cancer: Role of ATP-dependent transporters

被引：4599

作者：

Gottesman, MM ^{[1
]}

Fojo, T ^{[1
]}

Bates, SE ^{[1
]}

机构：

[1] Ctr Canc Res, Lab Cell Biol & Canc Therapeut Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 01期

关键词：

D O I：

10.1038/nrc706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs - a trait known as multidrug resistance - remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy.

引用

页码：48 / 58

页数：11

共 170 条

[11] DECREASED MUTATION-RATE FOR CELLULAR-RESISTANCE TO DOXORUBICIN AND SUPPRESSION OF MDR1 GENE ACTIVATION BY THE CYCLOSPORINE PSC-833 [J].

BEKETICORESKOVIC, L ;

DURAN, GE ;

CHEN, G ;

DUMONTET, C ;

SIKIC, BI .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (21) :1593-1602

[12] MOAT-E (ARA) is a full-length MRP cMOAT subfamily transporter expressed in kidney and liver [J].

Belinsky, MG ;

Kruh, GD .

BRITISH JOURNAL OF CANCER, 1999, 80 (09) :1342-1349

[13] Mutations in ABCC6 cause pseudoxanthoma elasticum [J].

Bergen, AAB ;

Plomp, AS ;

Schuurman, EJ ;

Terry, S ;

Breuning, M ;

Dauwerse, H ;

Swart, J ;

Kool, M ;

van Soest, S ;

Baas, F ;

ten Brink, JB ;

de Jong, PTVM .

NATURE GENETICS, 2000, 25 (02) :228-231

[14] DIFFERENTIAL INHIBITION BY CYCLOSPORINS OF PRIMARY-ACTIVE ATP-DEPENDENT TRANSPORTERS IN THE HEPATOCYTE CANALICULAR MEMBRANE [J].

BOHME, M ;

BUCHLER, M ;

MULLER, M ;

KEPPLER, D .

FEBS LETTERS, 1993, 333 (1-2) :193-196

[15] A family of drug transporters: The multidrug resistance-associated proteins [J].

Borst, P ;

Evers, R ;

Kool, M ;

Wijnholds, J .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (16) :1295-1302

[16] ABC transporters in lipid transport [J].

Borst, P ;

Zelcer, N ;

van Helvoort, A .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1486 (01) :128-144

[17] Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance [J].

Bradshaw, DM ;

Arceci, RJ .

JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (11) :3674-3690

[18] Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia [J].

Broxterman, HJ ;

Sonneveld, P ;

Pieters, R ;

Lankelma, J ;

Eekman, CA ;

Loonen, AH ;

Schoester, M ;

Ossenkoppele, GJ ;

Löwenberg, B ;

Pinedo, HM ;

Schuurhuis, GJ .

LEUKEMIA, 1999, 13 (02) :258-265

[19] Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice [J].

Bunting, KD ;

Galipeau, J ;

Topham, D ;

Benaim, E ;

Sorrentino, BP .

BLOOD, 1998, 92 (07) :2269-2279

[20]

BURGER H, 1994, LEUKEMIA, V8, P990

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