BANK1 Is a Genetic Risk Factor for Diffuse Cutaneous Systemic Sclerosis and Has Additive Effects With IRF5 and STAT4

被引：92

作者：

Dieude, P. ^{[3
]}

Wipff, J. ^{[2
]}

Guedj, A. ^{[4
]}

Ruiz, B. ^{[2
]}

Melchers, I. ^{[5
]}

Hachulla, E. ^{[6
]}

Riemekasten, G. ^{[7
]}

Diot, E. ^{[8
]}

Hunzelmann, N. ^{[9
]}

Sibilia, J. ^{[10
]}

Tiev, K. ^{[11
]}

Mouthon, L. ^{[12
]}

Cracowski, J. L. ^{[13
]}

Carpentier, P. H.

Distler, J. ^{[14
]}

Amoura, Z. ^{[15
]}

Tarner, I. ^{[16
]}

Avouac, J. ^{[2
]}

Meyer, O. ^{[3
]}

Kahan, A. ^{[17
]}

Boileau, C. ^{[2
,18
]}

Allanore, Y. ^{[1
,2
]}

机构：

[1] Hop Cochin, Serv Rhumatol A, F-75014 Paris, France

[2] Univ Paris 05, INSERM, U781, Hop Necker, Paris, France

[3] Univ Paris 07, Hop Bichat Claude Bernard, AP HP, Paris, France

[4] Univ Evry Val Essonne, UMR 8071, CNRS, INRA 1152, Evry, France

[5] Univ Med Ctr, Freiberg, Germany

[6] Univ Lille 2, Lille, France

[7] Charite, D-13353 Berlin, Germany

[8] Univ Bretonneau, INSERM, U618, IFR 135,Ctr Hosp, Tours, France

[9] Univ Cologne, Cologne, Germany

[10] Univ Strasbourg, Hop Hautepierre, Strasbourg, France

[11] Univ Paris 06, Hop St Antoine, AP HP, Paris, France

[12] Univ Paris 05, Hop Cochin, AP HP, Paris, France

[13] Univ Grenoble, INSERM, CIC3, Ctr Hosp, Grenoble, France

[14] Univ Erlangen Nurnberg, Erlangen, Germany

[15] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Paris, France

[16] Univ Giessen, Kerckhoff Clin, Giessen, Germany

[17] Univ Paris 05, Hop Cochin, Paris, France

[18] Univ Versailles St Quentin Yvelines, Hop Ambroise Pare, AP HP, Boulogne, France

来源：

ARTHRITIS AND RHEUMATISM | 2009年 / 60卷 / 11期

关键词：

ASSOCIATION; SUSCEPTIBILITY; POLYMORPHISM; SCLERODERMA; SUBSETS;

D O I：

10.1002/art.24885

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4. Methods. BANK1 single-nucleotide polymorphisms were genotyped in a total population of 2,432 individuals. The French cohort consisted of 874 SSc patients and 955 controls (previously genotyped for both IRF5 rs2004640 and STAT4 rs7574865). The German cohort consisted of 421 SSc patients and 182 controls. Results. The BANK1 variants were found to be associated with diffuse cutaneous SSc (dcSSc) in both cohorts, providing an odds ratio (OR) of 0.77 for the rs10516487 T rare allele in the combined populations of dcSSc patients as compared with the combined populations of controls (95% confidence interval [95% CI] 0.64-0.93) and an OR of 0.73 (95% CI 0.61-0.87) for the rs3733197 A rare allele. BANK1 haplotype analysis found the A-T haplotype to be protective in dcSSc patients (OR 0.70 [95% CI 0.57-0.86], P = 3.39 x 10(-4)) and the G-C haplotype to be a risk factor (OR 1.25 [95% CI 1.06-1.47], P = 0.008). Significant differences were also observed when the limited cutaneous subset of SSc was compared with the dcSSc subset, both for the rare alleles and for the haplotypes. The BANK1, IRF5, and STAT4 risk alleles displayed a multiplicatively increased risk of dcSSc of 1.43-fold. Conclusion. Our results establish BANK1 as a new SSc genetic susceptibility factor and show that BANK1, IRF5, and STAT4 act with additive effects.

引用

页码：3447 / 3454

页数：8

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