Kinetic pathway of spontaneous vesicle formation

被引：70

作者：

Leng, J ^{[1
]}

Egelhaaf, SU ^{[1
]}

Cates, ME ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland

来源：

EUROPHYSICS LETTERS | 2002年 / 59卷 / 02期

关键词：

D O I：

10.1209/epl/i2002-00243-1

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The spontaneous formation of lipid vesicles (liposomes) in aqueous lecithin/bile salt mixtures is studied using time-resolved static and dynamic light scattering. These measurements reveal a strong dependence of the kinetic rates and end-state liposome properties on total amphiphile concentration and, even more pronounced, on ionic strength. The observed trends contradict equilibrium calculations, but are in quantitative agreement with a kinetic model that we present. This model identifies the key kinetic steps during vesicle formation: rapid formation of disc-like intermediate micelles, growth of these micelles and closure to form vesicles. This work offers conclusive evidence for kinetic rather than thermodynamic control of the end-state properties.

引用

页码：311 / 317

页数：7

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