Enantioselective addition of diethylzinc to aldehydes in the presence of chiral hydrazone and imine ligands

被引：18

作者：

Mino, Takashi

Suzuki, Atsushi

Yamashita, Masakazu

Narita, Shusaku

Shirae, Yoshiaki

Sakamoto, Masami

Fujita, Tsutomu

机构：

[1] Chiba Univ, Fac Engn, Dept Appl Chem & Biotechnol, Inage Ku, Chiba 2638522, Japan

[2] Doshisha Univ, Fac Engn, Dept Mol Sci & Technol, Kyoto 6100394, Japan

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2006年 / 691卷 / 20期

关键词：

hydrazone; imine; enantioselective addition; diethylzinc; secondary alcohol;

D O I：

10.1016/j.jorganchem.2006.07.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Optically active hydrazone and imine were found to act as effective ligands for enantio selective addition of diethylzinc to aldehydes. This reaction provided optically active secondary alcohols with ee up to 71%. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：4297 / 4303

页数：7

共 33 条

[31] CHIRAL N,N-DIALKYLNOREPHEDRINES AS CATALYSTS OF THE HIGHLY ENANTIOSELECTIVE ADDITION OF DIALKYLZINCS TO ALIPHATIC AND AROMATIC-ALDEHYDES - THE ASYMMETRIC-SYNTHESIS OF SECONDARY ALIPHATIC AND AROMATIC ALCOHOLS OF HIGH OPTICAL PURITY [J].