Molecular angiogenesis

被引:220
作者
Klagsbrun, M [1 ]
Moses, MA
机构
[1] Childrens Hosp, Dept Surg, Boston, MA 02115 USA
[2] Childrens Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源
CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 08期
关键词
D O I
10.1016/S1074-5521(99)80081-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
New insights into the mechanisms by which blood vessels develop (angiogenesis) have been gained recently, primarily by the identification of factors that inhibit and promote this process. Angiogenesis-stimulating factors are being used to promote growth of new blood vessels in ischemic disease. In contrast, anti-angiogenesis factors are being used as inhibitors of neovascularization to control tumor growth and metastasis.
引用
收藏
页码:R217 / R224
页数:8
相关论文
共 70 条
[21]   DOMINANT-NEGATIVE AND TARGETED NULL MUTATIONS IN THE ENDOTHELIAL RECEPTOR TYROSINE KINASE, TEK, REVEAL A CRITICAL ROLE IN VASCULOGENESIS OF THE EMBRYO [J].
DUMONT, DJ ;
GRADWOHL, G ;
FONG, GH ;
PURI, MC ;
GERTSENSTEIN, M ;
AUERBACH, A ;
BREITMAN, ML .
GENES & DEVELOPMENT, 1994, 8 (16) :1897-1909
[22]  
Dvorak HF, 1999, CURR TOP MICROBIOL, V237, P97
[23]   The role of αv integrins during angiogenesis [J].
Eliceiri, BP ;
Cheresh, DA .
MOLECULAR MEDICINE, 1998, 4 (12) :741-750
[24]   Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene [J].
Ferrara, N ;
CarverMoore, K ;
Chen, H ;
Dowd, M ;
Lu, L ;
OShea, KS ;
PowellBraxton, L ;
Hillan, KJ ;
Moore, MW .
NATURE, 1996, 380 (6573) :439-442
[25]  
Ferrara N, 1999, CURR TOP MICROBIOL, V237, P1
[26]   ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].
FOLKMAN, J .
NATURE MEDICINE, 1995, 1 (01) :27-31
[27]   Blood vessel formation: What is its molecular basis? [J].
Folkman, J ;
DAmore, PA .
CELL, 1996, 87 (07) :1153-1155
[28]   ROLE OF THE FLT-1 RECEPTOR TYROSINE KINASE IN REGULATING THE ASSEMBLY OF VASCULAR ENDOTHELIUM [J].
FONG, GH ;
ROSSANT, J ;
GERTSENSTEIN, M ;
BREITMAN, ML .
NATURE, 1995, 376 (6535) :66-70
[29]  
Fong TAT, 1999, CANCER RES, V59, P99
[30]   Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [J].
Goldman, CK ;
Kendall, RL ;
Cabrera, G ;
Soroceanu, L ;
Heike, Y ;
Gillespie, GY ;
Siegal, GP ;
Mao, XZ ;
Bett, AJ ;
Huckle, WR ;
Thomas, KA ;
Curiel, DT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8795-8800