Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development

被引：39

作者：

Vicini, P. ^{[1
,2
,3
]}

Fields, O. ^{[1
,2
,3
,4
]}

Lai, E.

Litwack, E. D. ^{[5
]}

Martin, A-M ^{[6
]}

Morgan, T. M. ^{[7
,8
]}

Pacanowski, M. A. ^{[5
]}

Papaluca, M. ^{[9
]}

Perez, O. D. ^{[1
,2
,3
]}

Ringel, M. S. ^{[10
]}

Robson, M. ^{[7
,8
]}

Sakul, H. ^{[1
,2
,3
]}

Vockley, J. ^{[11
]}

Zaks, T. ^{[12
]}

Dolsten, M. ^{[1
,2
,3
]}

Sogaard, M. ^{[1
,2
,3
]}

机构：

[1] Pfizer Worldwide Res & Dev, La Jolla, CA USA

[2] Pfizer Worldwide Res & Dev, Collegeville, PA USA

[3] Pfizer Worldwide Res & Dev, New York, NY USA

[4] Takeda Pharmaceut Int, Deerfield, IL USA

[5] US FDA, Silver Spring, MD USA

[6] GlaxoSmithKline, Collegeville, PA USA

[7] Novartis Inst Biomed Res, Cambridge, MA USA

[8] Novartis Inst Biomed Res, E Hanover, NJ USA

[9] European Med Agcy, London, England

[10] Boston Consulting Grp Inc, Boston, MA USA

[11] Inova Translat Med Inst, Falls Church, VA USA

[12] Sanofi, Cambridge, MA USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 99卷 / 02期

关键词：

RESEARCH-AND-DEVELOPMENT; PERSONALIZED MEDICINE; INCIDENTAL FINDINGS; CLINICAL GENOME; CHALLENGES; DIAGNOSIS; EXOME; ONCOLOGY; RECOMMENDATIONS; IMPLEMENTATION;

D O I：

10.1002/cpt.293

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

High throughput molecular and functional profiling of patients is a key driver of precision medicine. DNA and RNA characterization has been enabled at unprecedented cost and scale through rapid, disruptive progress in sequencing technology, but challenges persist in data management and interpretation. We analyze the state-of-the-art of large-scale unbiased sequencing in drug discovery and development, including technology, application, ethical, regulatory, policy and commercial considerations, and discuss issues of LUS implementation in clinical and regulatory practice.

引用

页码：198 / 207

页数：10

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