Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice

被引：17

作者：

Asanuma, M

Miyazaki, I

Higashi, Y

Cadet, JL

Ogawa, N

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Brain Sci, Okayama 7008558, Japan

[2] NIDA, Mol Neuropsychiat Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 325卷 / 03期

关键词：

methamphetamine; p53; DNA-binding activity; superoxide dismutase; reactive oxygen species;

D O I：

10.1016/S0304-3940(02)00291-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The striatal DNA-binding activities of p53 as a transcription factor were gradually increased at several days after a single methamphetamine (METH) injection, while they were more rapidly increased within several hours after repeated METH injections (x 4 with a 2 h interval). The elevation of striatal p53 DNA-binding after repeated METH injections was markedly attenuated in Cu,Zn-superoxide dismutase transgenic mice, but not affected by treatments with N-methyl-Daspartate or D1 receptor antagonists. The present results suggest that METH-induced production of reactive oxygen species activates striatal p53 DNA-binding activity; this, in turn, may activate other downstream pathways that are responsible for chronic neurotoxicity of METH. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

共 16 条

[1] Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice [J].