The histopathology of carp, Cyprinus carpio L, exposed to microcystins by gavage, immersion and intraperitoneal administration

Carp liver, gills, intestine, kidneys, heart and spleen were studied by histology after the fish were exposed to microcystins by gavage, immersion and intraperitoneal administration. Intraperitoneal inoculation with microcystins caused necrosis or dose-dependent degeneration in the liver, gills and kidneys. Gavaging with microcystins caused changes in the histopathology of the liver and gills. Cellular degeneration and necrosis occurred in the liver, gills and kidneys when carp were introduced to a tank containing 1.7 mu ml(-1) of microcystins. Lesions were not observed in the heart, spleen or intestines from any of the treated carp. Microcystins administered by intraperitoneal injection at a concentration of 50 mu g kg(-1) were lethal to all fish within 8 h, while gavaging with 250 mu g kg(-1) of microcystins caused minimal damage in the tissues studied.