Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

被引：359

作者：

Kagan, Valerian E. ^{[1
,2
]}

Bayir, Huelya A. ^{[1
,3
,4
]}

Belikova, Natalia A. ^{[1
,2
]}

Kapralov, Olexandr ^{[1
,2
]}

Tyurina, Yulia Y. ^{[1
,2
]}

Tyurin, Vladimir A. ^{[1
,2
]}

Jiang, Jianfei ^{[1
,2
]}

Stoyanovsky, Detcho A. ^{[5
]}

Wipf, Peter ^{[6
]}

Kochanek, Patrick M. ^{[3
,4
]}

Greenberger, Joel S. ^{[7
]}

Pitt, Bruce ^{[2
]}

Shvedova, Anna A. ^{[8
]}

Borisenko, Grigory ^{[9
]}

机构：

[1] Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15219 USA

[2] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15219 USA

[3] Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA

[4] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15260 USA

[5] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USA

[6] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[7] Univ Pittsburgh, Dept Radiat Oncol, Pittsburgh, PA 15260 USA

[8] NIOSH, Physiol Pathol Res Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA

[9] Res Inst Physicochem Med, Moscow, Russia

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2009年 / 46卷 / 11期

关键词：

Cytochrome c; Cardiolipin; Peroxidase; Lipidomics; Oxidative stress; Apoptosis; Autophagy; Mitochondrial targeting; Free radicals; ELECTRON-TRANSPORT CHAIN; OXIDATIVE LIPIDOMICS; PEROXIDASE-ACTIVITY; MONOLYSOCARDIOLIPIN ACYLTRANSFERASE; PHOSPHOLIPID SCRAMBLASE-3; HORSERADISH-PEROXIDASE; HYDROGEN-PEROXIDE; COMPOUND-I; CARDIOLIPIN PEROXIDATION; STRUCTURAL TRANSITIONS;

D O I：

10.1016/j.freeradbiomed.2009.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria-its asymmetric transmembrane distribution and mechanisms of collapse, the regulation of its synthesis, remodeling, and fatty acid composition-are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented. Published by Elsevier Inc.

引用

页码：1439 / 1453

页数：15

共 169 条

[11] Selective early cardiolipin peroxidation after traumatic brain injury: An oxidative lipidomics analysis [J].

Bayir, Huelya ;

Tyurin, Vladimir A. ;

Tyurina, Yulia Y. ;

Viner, Rosa ;

Ritov, Vladimir ;

Amoscato, Andrew A. ;

Zhao, Qing ;

Zhang, Xiaojing J. ;

Janesko-Feldman, Keri L. ;

Alexander, Henry ;

Basova, Liana V. ;

Clark, Robert S. B. ;

Kochanek, Patrick M. ;

Kagan, Valerian E. .

ANNALS OF NEUROLOGY, 2007, 62 (02) :154-169

[12]

Bazan NG, 2005, BRAIN PATHOL, V15, P159

[13]

Bazan NG, 2008, ADV EXP MED BIOL, V613, P39

[14] Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection [J].

Bazan, Nicolas G. .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (02) :136-141

[15] Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes [J].

Belikova, NA ;

Vladimirov, YA ;

Osipov, AN ;

Kapralov, AA ;

Tyurin, VA ;

Potapovich, MV ;

Basova, LV ;

Peterson, J ;

Kurnikov, IV ;

Kagan, VE .

BIOCHEMISTRY, 2006, 45 (15) :4998-5009

[16] Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis [J].

Belikova, Natalia A. ;

Jiang, Jianfei ;

Tyurina, Yulia Y. ;

Zhao, Qing ;

Epperly, Michael W. ;

Greenberger, Joel ;

Kagan, Valerian E. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (01) :176-186

[17] Interaction of horse heart and Thermus thermophilus type c cytochromes with phospholipid vesicles and hydrophobic surfaces [J].

Bernad, S ;

Oellerich, S ;

Soulimane, T ;

Noinville, S ;

Baron, MH ;

Paternostre, M ;

Lecomte, S .

BIOPHYSICAL JOURNAL, 2004, 86 (06) :3863-3872

[18] The stability of the cytochrome c scaffold as revealed by NMR spectroscopy [J].

Berners-Price, SJ ;

Bertini, I ;

Gray, HB ;

Spyroulias, GA ;

Turano, P .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (05) :814-823

[19] Molecular Design of New Inhibitors of Peroxidase Activity of Cytochrome c/Cardiolipin Complexes: Fluorescent Oxadiazole-Derivatized Cardiolipin [J].

Borisenko, G. G. ;

Kapralov, A. A. ;

Tyurin, V. A. ;

Maeda, A. ;

Stoyanovsky, D. A. ;

Kagan, V. E. .

BIOCHEMISTRY, 2008, 47 (51) :13699-13710

[20] A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse [J].

Cao, JS ;

Liu, YF ;

Lockwood, J ;

Burn, P ;

Shi, YG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) :31727-31734

← 1 2 3 4 5 6 7 8 9 10 →