Out of Eden: Stem cells and their niches

被引：1246

作者：

Watt, FM

Hogan, BLM

机构：

[1] Imperial Canc Res Fund, Keratinocyte Lab, London WC2A 3PX, England

[2] Vanderbilt Univ, Med Ctr, Dept Cell Biol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Howard Hughes Med Inst, Nashville, TN 37232 USA

来源：

SCIENCE | 2000年 / 287卷 / 5457期

关键词：

D O I：

10.1126/science.287.5457.1427

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell Lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

引用

页码：1427 / 1430

页数：4

共 59 条

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