Caffeic Acid Phenethyl Ester, an Antioxidant from Propolis, Protects Peripheral Blood Mononuclear Cells of Competitive Cyclists against Hyperthermal Stress

被引：31

作者：

Chen, Yu-Jen ^{[1
,2
]}

Huang, Ai-Chun ^{[3
]}

Chang, Hen-Hong ^{[4
,5
]}

Liao, Hui-Fen ^{[6
]}

Jiang, Chii-Ming ^{[7
]}

Lai, Li-Yun ^{[8
]}

Chan, Jen-Te ^{[9
]}

Chen, Yu-Yawn ^{[9
]}

Chiang, Jasson ^{[1
]}

机构：

[1] Chinese Culture Univ, Grad Inst Sport Coaching Sci, Taipei 111, Taiwan

[2] Mackay Mem Hosp, Dept Radiat Oncol, Taipei, Taiwan

[3] Tzu Hui Inst Technol, Pingtung 926, Taiwan

[4] Chang Gung Tradit Chinese Med Hosp, Tao Yuan 333, Taiwan

[5] Chang Gung Univ, Sch Tradit Chinese Med, Tao Yuan 333, Taiwan

[6] Natl Chiayi Univ, Dept Mol Biol & Biochem, Chiayi 300, Taiwan

[7] Natl Kaohsiung Inst Marine Technol, Dept Seafood Sci, Kaohsiung 811, Taiwan

[8] Chinese Culture Univ, Dept Phys Educ, Taipei 111, Taiwan

[9] Natl Taiwan Sport Univ, Dept & Grad Sch Phys Educ, Taichung, Taiwan

来源：

JOURNAL OF FOOD SCIENCE | 2009年 / 74卷 / 06期

关键词：

caffeic acid phenethyl ester (CAPE); cyclist; glutathione; hyperthermia; mononuclear cell; LEUKEMIC HL-60 CELLS; PROLONGED EXERCISE; OXIDATIVE STRESS; SKELETAL-MUSCLE; EXPRESSION; INHIBITION; LEUKOCYTES; APOPTOSIS; HEAT; GENE;

D O I：

10.1111/j.1750-3841.2009.01199.x

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Hyperthermal stress and resulting free radical generation is known to impair endurance capacity and immune cell redistribution during prolonged exercise. Caffeic acid phenethyl ester (CAPE), a phenolic compound purified from propolis, has many biological and pharmacological activities including antioxidation. To examine whether CAPE has protective effect against hyperthermal stress in athletes, we isolated peripheral blood mononuclear cells (MNC) from competitive cyclists and assessed their response to hyperthermia with or without CAPE pretreatment. We found that pretreatment of cyclists' MNC with CAPE (0, 1, 2, 4 mu g/mL) reversed or reduced hyperthermia-induced survival inhibition, necrosis, superoxide production, glutathione depletion, and intracellular superoxide burst in a dose-dependent manner. These results suggest that CAPE may enhance the hyperthermal tolerance in immune mononuclear cells of competitive cyclists.

引用

页码：H162 / H167

页数：6

共 23 条

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