Effect of temperature and fixation on the optical properties of atherosclerotic tissue: a validation study of an ex-vivo whole heart cadaveric model

被引：16

作者：

Gnanadesigan, Muthukaruppan ^{[1
]}

van Soest, Gijs ^{[1
]}

White, Stephen ^{[2
]}

Scoltock, Simon ^{[2
]}

Ughi, Giovanni J. ^{[4
,5
]}

Baumbach, Andreas ^{[2
]}

van der Steen, Antonius F. W. ^{[1
,3
]}

Regar, Evelyn ^{[1
]}

Johnson, Thomas W. ^{[2
]}

机构：

[1] Erasmus MC, Dept Biomed Engn, NL-3000 CA Rotterdam, Netherlands

[2] Bristol Heart Inst, Bristol, Avon, England

[3] Delft Univ Technol, Dept Imaging Sci & Technol, NL-2628 CJ Delft, Netherlands

[4] Katholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium

[5] Katholieke Univ Leuven, Dept Cardiovasc Sci, Louvain, Belgium

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 04期

关键词：

COHERENCE TOMOGRAPHY IMAGES; VASCULAR-RESPONSE; SCATTERING MEDIA; PLAQUE; STENTS;

D O I：

10.1364/BOE.5.001038

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Atherosclerotic plaque composition can be imaged using the optical attenuation coefficient derived from intravascular optical coherence tomography (OCT) data. The relation between optical properties and tissue type has been established on autopsy tissues. In this study, we validate an ex-vivo model for the effect of temperature and tissue fixation on optical parameters. We studied the optical attenuation of human coronary arteries at three temperatures, before and after formalin fixation. We developed an en-face longitudinal display of attenuation data of the OCT pullbacks. Using the unfixed, body-temperature condition image as a standard, and after extensive registration with other condition images, we quantify the differences in optical attenuation and the backscattered intensity. The results suggest that tissue fixation and temperature do not introduce systematic errors in studies of arterial optical properties. (C) 2014 Optical Society of America

引用

页码：1038 / 1049

页数：12

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