Mechanistic considerations of halogenating enzymes

被引：262

作者：

Butler, Alison ^{[1
]}

Sandy, Moriah ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

NATURE | 2009年 / 460卷 / 7257期

基金：

美国国家科学基金会;

关键词：

METHYL-CHLORIDE TRANSFERASE; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE; VANADIUM BROMOPEROXIDASE; NATURAL-PRODUCT; HETEROLOGOUS EXPRESSION; CURVULARIA-INAEQUALIS; STREPTOMYCES-CATTLEYA; ASCOPHYLLUM-NODOSUM; GENE-CLUSTER;

D O I：

10.1038/nature08303

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In nature, halogenation is a strategy used to increase the biological activity of secondary metabolites, compounds that are often effective as drugs. However, halides are not particularly reactive unless they are activated, typically by oxidation. The pace of discovery of new enzymes for halogenation is increasing, revealing new metalloenzymes, flavoenzymes, S-adenosyl-l-methionine (SAM)-dependent enzymes and others that catalyse halide oxidation using dioxygen, hydrogen peroxide and hydroperoxides, or that promote nucleophilic halide addition reactions.

引用

页码：848 / 854

页数：7

共 60 条

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