Innovative lead discovery strategies for tropical diseases

被引：429

作者：

Nwaka, Solomon ^{[1
]}

Hudson, Alan ^{[1
]}

机构：

[1] World Hlth Org, Special Programme Res & Training Trop Dis, Geneva, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrd2144

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lead discovery is currently a key bottleneck in the pipeline for much-needed novel drugs for tropical diseases such as malaria, tuberculosis, African sleeping sickness, leishmaniasis and Chagas disease. Here, we discuss the different approaches to lead discovery for tropical diseases and emphasize a coordination strategy that involves highly integrated partnerships and networks between scientists in academic institutions and industry in both wealthy industrialized countries and disease-endemic countries. This strategy offers the promise of reducing the inherently high attrition rate of the early stages of discovery research, thereby increasing the chances of success and enhancing cost-effectiveness.

引用

页码：941 / 955

页数：15

共 70 条

[61] High-throughput screening in academia: The Harvard experience [J].

Stein, RL .

JOURNAL OF BIOMOLECULAR SCREENING, 2003, 8 (06) :615-619

[62] Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue [J].

Sturk, LM ;

Brock, JL ;

Bagnell, CR ;

Hall, JE ;

Tidwell, RR .

ACTA TROPICA, 2004, 91 (02) :131-143

[63] Drug development for neglected diseases: a deficient market and a public-health policy failure [J].

Trouiller, P ;

Olliaro, P ;

Torreele, E ;

Orbinski, J ;

Laing, R ;

Ford, N .

LANCET, 2002, 359 (9324) :2188-2194

[64] Identification of an antimalarial synthetic trioxolane drug development candidate [J].

Vennerstrom, JL ;

Arbe-Barnes, S ;

Brun, R ;

Charman, SA ;

Chiu, FCK ;

Chollet, J ;

Dong, YX ;

Dorn, A ;

Hunziker, D ;

Matile, H ;

McIntosh, K ;

Padmanilayam, M ;

Tomas, JS ;

Scheurer, C ;

Scorneaux, B ;

Tang, YQ ;

Urwyler, H ;

Wittlin, S ;

Charman, WN .

NATURE, 2004, 430 (7002) :900-904

[65]

*WHO, 2004, WORLD HLTH REP

[66] Current strategies in the search for novel antiparasitic agents [J].

Witty, MJ .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1999, 29 (01) :95-103

[67]

YATES I, 2003, DRUG DISCOV WORLD, V4, P35

[68] Insights into antifolate resistance from malarial DHFR-TS structures [J].

Yuvaniyama, J ;

Chitnumsub, P ;

Kamchonwongpaisan, S ;

Vanichtanankul, J ;

Sirawaraporn, W ;

Taylor, P ;

Walkinshaw, MD ;

Yuthavong, Y .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (05) :357-365

[69]

2005, G8 GLENEAGLES COMMUN

[70]

2004, TDR NEWS

← 1 2 3 4 5 6 7 →