Antitumor agents. Part 214: Synthesis and evaluation of curcumin analogues as cytotoxic agents

被引：137

作者：

Ishida, J

Ohtsu, H

Tachibana, Y

Nakanishi, Y

Bastow, KF

Nagai, M

Wang, HK

Itokawa, H

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Hoshi Univ, Shinagawa Ku, Tokyo 1580098, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0968-0896(02)00249-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound 50 was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 mug/mL, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：3481 / 3487

页数：7

相关论文

共 20 条

[1] Curcumin is an in vivo inhibitor of angiogenesis [J].

Arbiser, JL ;

Klauber, N ;

Rohan, R ;

van Leeuwen, R ;

Huang, MT ;

Fisher, C ;

Flynn, E ;

Byers, HR .

MOLECULAR MEDICINE, 1998, 4 (06) :376-383

[2] STYRYLPYRAZOLES, STYRYLISOXAZOLES, AND STYRYLISOTHIAZOLES - NOVEL 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS [J].

FLYNN, DL ;

BELLIOTTI, TR ;

BOCTOR, AM ;

CONNOR, DT ;

KOSTLAN, CR ;

NIES, DE ;

ORTWINE, DF ;

SCHRIER, DJ ;

SIRCAR, JC .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :518-525

[3] Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis [J].

Ishida, J ;

Kozuka, M ;

Wang, HK ;

Konoshima, T ;

Tokuda, H ;

Okuda, M ;

Mou, XY ;

Nishino, H ;

Sakurai, N ;

Lee, KH ;

Nagai, M .

CANCER LETTERS, 2000, 159 (02) :135-140

[4]

ISHIDA J, IN PRESS BIOORG MED

[5] How curcumin works preferentially with water soluble antioxidants [J].

Jovanovic, SV ;

Boone, CW ;

Steenken, S ;

Trinoga, M ;

Kaskey, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (13) :3064-3068

[6] Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells [J].

Kuo, ML ;

Huang, TS ;

Lin, JK .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1996, 1317 (02) :95-100

[7] CHEMISTRY AND BIOCHEMISTRY OF CHINESE DRUGS .6. CYTO-TOXIC COMPONENTS OF ZINGIBER-ZERUMBET, CURCUMA-ZEDOARIA AND CURCUMA-DOMESTICA [J].

MATTHES, HWD ;

LUU, B ;

OURISSON, G .

PHYTOCHEMISTRY, 1980, 19 (12) :2643-2650

[8]

MAZZUMDER A, 1997, J MED CHEM, V40, P3057

[9]

Nadkarni K.M., 1976, INDIAN METERIA MED, P414

[10]

Nogaki A, 1998, ANTICANCER RES, V18, P3487