Synthesis and NMR studies of cyclopeptides containing a sugar amino acid

被引：45

作者：

Stöckle, M ^{[1
]}

Voll, G ^{[1
]}

Günther, R ^{[1
]}

Lohof, E ^{[1
]}

Locardi, E ^{[1
]}

Gruner, S ^{[1
]}

Kessler, H ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 15期

关键词：

D O I：

10.1021/ol026126d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] Cyclopeptides containing Glucuronic acid methylamine (Gum) alternating with Gly, L-Ala, D-Ala, L-Phe, D-Phe, L-Lys, or D-Lys were synthesized by a combination of solid-phase synthesis and solution chemistry. A more effective pathway to synthesize the sugar amino acid Gum in higher yields and in a shorter period of time was developed. Gum is employed in the benzylated and deprotected form. The cyclopeptides were characterized by NMR and the structure of one deprotected cyclic peptide solved.

引用

页码：2501 / 2504

页数：4

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