The role of caveolin-1 in androgen insensitive prostate cancer

被引：66

作者：

Mouraviev, V ^{[1
]}

Li, LK

Tahir, SA

Yang, G

Timme, TL

Goltsov, A

Ren, CZ

Satoh, T

Wheeler, TM

Ittmann, MM

Miles, BJ

Amato, RJ

Kadmon, D

Thompson, TC

机构：

[1] Baylor Coll Med, Vet Affairs Med Ctr, Scott Dept Urol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Cell & Mol Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Radiol, Houston, TX 77030 USA

来源：

JOURNAL OF UROLOGY | 2002年 / 168卷 / 04期

关键词：

prostate; prostatic neoplasms; caveolins; neoplasm metastasis; androgens;

D O I：

10.1016/S0022-5347(05)64526-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport. Materials and Methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.

引用

页码：1589 / 1596

页数：8

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