Genetic toxicology of epichlorohydrin: A review

被引：55

作者：

Giri, AK

机构：

[1] Indian Institute of Chemical Biology, Jadavpur, Calcutta 700 032

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 1997年 / 386卷 / 01期

关键词：

mutagenicity; clastogenicity; genetic toxicology; epichlorohydrin;

D O I：

10.1016/S1383-5742(96)00042-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Epichlorohydrin (ECH) is one of the more commercially important aliphatic epoxides used extensively as an industrial intermediate, a laboratory reagent, and as an insecticide. It is a volatile, colourless liquid with an ethereal odour. It behaves as an alkylating agent. Reports have shown it to cause the respiratory and der-mal toxicity in animals and humans. It has also been reported to be carcinogenic in experimental models. Thus, the wide-spread use of this aliphatic epoxide is of great concern in human health problem. The purpose of this paper is to critically review and update the mutagenic and clastogenic effects of ECH based on available literature.

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收藏

页码：25 / 38

页数：14

相关论文

共 125 条

[31] INVITRO CHROMOSOME ASSAY USING CULTURED RAT-LIVER CELLS [J].

DEAN, BJ ;

HODSONWALKER, G .

MUTATION RESEARCH, 1979, 64 (05) :329-337

[32] METABOLIC-ACTIVATION AND DEACTIVATION OF MUTAGENS BY PREPARATIONS OF HUMAN-LUNG PARENCHYMA AND BRONCHIAL TREE [J].

DEFLORA, S ;

BENNICELLI, C ;

ZANACCHI, P ;

CAMOIRANO, A ;

PETRUZZELLI, S ;

GIUNTINI, C .

MUTATION RESEARCH, 1984, 139 (01) :9-14

[33] CYTOGENETIC MONITORING OF INDUSTRIAL-POPULATIONS POTENTIALLY EXPOSED TO GENOTOXIC CHEMICALS AND OF CONTROL POPULATIONS [J].

DEJONG, G ;

VANSITTERT, NJ ;

NATARAJAN, AT .

MUTATION RESEARCH, 1988, 204 (03) :451-464

[34] MUTAGENIC POTENTIAL OF ALLYL AND ALLYLIC COMPOUNDS - STRUCTURE-ACTIVITY RELATIONSHIP AS DETERMINED BY ALKYLATING AND DIRECT INVITRO MUTAGENIC PROPERTIES [J].

EDER, E ;

NEUDECKER, T ;

LUTZ, D ;

HENSCHLER, D .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (07) :993-998

[35] GENETIC TOXICITY OF SOME IMPORTANT EPOXIDES [J].

EHRENBERG, L ;

HUSSAIN, S .

MUTATION RESEARCH, 1981, 86 (01) :1-113

[36] VINYL-CHLORIDE MUTAGENICITY VIA METABOLITES CHLORO-OXIRANE AND CHLOROACETALDEHYDE MONOMER HYDRATE [J].

ELMORE, JD ;

WONG, JL ;

LAUMBACH, AD ;

STREIPS, UN .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 442 (03) :405-419

[37] DETECTION OF CHEMICAL MUTAGENS BY DOMINANT LETHAL ASSAY IN MOUSE [J].

EPSTEIN, SS ;

BASS, W ;

BISHOP, Y ;

ARNOLD, E ;

ANDREA, J .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1972, 23 (02) :288-&

[38]

EVANS EL, 1981, PROGR MUTATION RES, V1, P538

[39]

GAGE JC, 1956, BR J IND MED, V16, P11

[40] SISTER-CHROMATID EXCHANGE AND CHROMOSOME-ABERRATIONS FOR 4 ALIPHATIC EPOXIDES IN MICE [J].

GIRI, AK ;

MESSERLY, EA ;

SINSHEIMER, JE .

MUTATION RESEARCH, 1989, 224 (02) :253-261

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