The PPARs: From orphan receptors to drug discovery

被引:1594
作者
Willson, TM [1 ]
Brown, PJ [1 ]
Sternbach, DD [1 ]
Henke, BR [1 ]
机构
[1] Glaxo Wellcome Inc, Res & Dev, Dept Med Chem, Res Triangle Pk, NC 27709 USA
关键词
D O I
10.1021/jm990554g
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:527 / 550
页数:24
相关论文
共 325 条
  • [1] Cloning and characterization of the 5′ flanking region of the human uncoupling protein 3 (UCP3) gene
    Acín, A
    Rodriguez, M
    Rique, H
    Canet, E
    Boutin, JA
    Galizzi, JP
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (02) : 278 - 283
  • [2] Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    Adams, M
    Reginato, MJ
    Shao, DL
    Lazar, MA
    Chatterjee, VK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) : 5128 - 5132
  • [3] Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    Aitman, TJ
    Glazier, AM
    Wallace, CA
    Cooper, LD
    Norsworthy, PJ
    Wahid, FN
    Al-Majali, KM
    Trembling, PM
    Mann, CJ
    Shoulders, CC
    Graf, D
    St Lezin, E
    Kurtz, TW
    Kren, V
    Pravenec, M
    Ibrahimi, A
    Abumrad, NA
    Stanton, LW
    Scott, J
    [J]. NATURE GENETICS, 1999, 21 (01) : 76 - 83
  • [4] SELECTIVE MODIFICATION OF RAT HEPATIC-MICROSOMAL FATTY-ACID CHAIN ELONGATION AND DESATURATION BY FIBRATES - RELATIONSHIP WITH PEROXISOME PROLIFERATION
    ALEGRET, M
    CERQUEDA, E
    FERRANDO, R
    VAZQUEZ, M
    SANCHEZ, RM
    ADZET, T
    MERLOS, M
    LAGUNA, JC
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (07) : 1351 - 1358
  • [5] RELATIONSHIP BETWEEN PLASMA-LIPIDS AND PALMITOYL-COA HYDROLASE AND SYNTHETASE ACTIVITIES WITH PEROXISOMAL PROLIFERATION IN RATS TREATED WITH FIBRATES
    ALEGRET, M
    FERRANDO, R
    VAZQUEZ, M
    ADZET, T
    MERLOS, M
    LAGUNA, JC
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 (02) : 551 - 556
  • [6] PPAR gamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A
    Altiok, S
    Xu, M
    Spiegelman, BM
    [J]. GENES & DEVELOPMENT, 1997, 11 (15) : 1987 - 1998
  • [7] CLONING OF A PROTEIN THAT MEDIATES TRANSCRIPTIONAL EFFECTS OF FATTY-ACIDS IN PREADIPOCYTES - HOMOLOGY TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
    AMRI, EZ
    BONINO, F
    AILHAUD, G
    ABUMRAD, NA
    GRIMALDI, PA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (05) : 2367 - 2371
  • [8] CDNA CLONING AND CHARACTERIZATION OF THE TRANSCRIPTIONAL ACTIVITIES OF THE HAMSTER PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR HAPPAR-GAMMA
    APERLO, C
    POGNONEC, P
    SALADIN, R
    AUWERX, J
    BOULUKOS, KE
    [J]. GENE, 1995, 162 (02) : 297 - 302
  • [9] MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS
    ASHBY, J
    BRADY, A
    ELCOMBE, CR
    ELLIOTT, BM
    ISHMAEL, J
    ODUM, J
    TUGWOOD, JD
    KETTLE, S
    PURCHASE, IFH
    [J]. HUMAN & EXPERIMENTAL TOXICOLOGY, 1994, 13 : S1 - S117
  • [10] Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells
    Aubert, J
    Champigny, O
    SaintMarc, P
    Negrel, R
    Collins, S
    Ricquier, D
    Ailhaud, G
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) : 606 - 611