Chiral shift reagent for amino acids based on resonance-assisted hydrogen bonding

被引：71

作者：

Chin, J

Kim, DC

Kim, HJ

Panosyan, FB

Kim, KM

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada

[2] Korea Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea

[3] Ewha Womans Univ, Dept Chem, Div Nano Sci, Seoul 120750, South Korea

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 15期

关键词：

D O I：

10.1021/ol049084x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral aldehyde that forms resonance-assisted hydrogen bonded imines with amino acids has been developed. This hydrogen bond not only increases the equilibrium constant for imine formation but also provides a highly downfield-shifted NMR singlet for evaluating enantiomeric excess and absolute stereochemistry of amino acids.

引用

收藏

页码：2591 / 2593

页数：3

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