Determination of absolute configurations of amines and amino acids using nonchiral derivatizing agents (NCDA) and deuterium NMR

被引：13

作者：

Chalard, P ^{[1
]}

Bertrand, M ^{[1
]}

Canet, I ^{[1
]}

Théry, V ^{[1
]}

Remuson, R ^{[1
]}

Jeminet, G ^{[1
]}

机构：

[1] Univ Clermont Ferrand 2, UMR CNRS 6504, Lab SEESIB, F-63177 Clermont Ferrand, France

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 16期

关键词：

D O I：

10.1021/ol006066g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Enantiomeric analysis end empirical determination of the absolute configuration of amines and amino acids can be easily performed using acetyl-d(3) chloride as a nonchiral derivatizing agent (deuterium probe) and deuterium NMR in a chiral solvent (Courtieu's method), In the case of amino acids, derivatization to amido esters, performed with methanol-d(4) and acetyl-d(3) chloride, gives a double opportunity for enantiomeric analysis.

引用

页码：2431 / 2434

页数：4

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