Control of fatty acid desaturation: a mechanism conserved from bacteria to humans

被引：134

作者：

Aguilar, Pablo S.

de Mendoza, Diego ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Inst Biol Mol & Celular Rosario, RA-2000 Rosario, Argentina

[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Dept Microbiol, RA-2000 Rosario, Argentina

[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[4] Inst Pasteur Montevideo, Montevideo 11400, Uruguay

来源：

MOLECULAR MICROBIOLOGY | 2006年 / 62卷 / 06期

关键词：

D O I：

10.1111/j.1365-2958.2006.05484.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unsaturated fatty acids (UFAs) have profound effects on the fluidity and function of biological membranes. Microorganisms, plants and animals regulate the synthesis of UFAs during changing environmental conditions as well as in response to nutrients. UFAs homeostasis in many organisms is achieved by feedback regulation of fatty acid desaturase gene transcription through signalling pathways that are governed by sensors embedded in cellular membranes. Here, we review recently discovered components of the regulatory machinery governing the transcription of fatty acid desaturases in bacteria, yeasts and animals that indicate an ancient role of transmembrane signalling mechanisms and integrate membrane composition with lipid biosynthesis.

引用

页码：1507 / 1514

页数：8

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