Database of bronchoalveolar lavage fluid proteins

被引：102

作者：

Noël-Georis, I

Bernard, A

Falmagne, P

Wattiez, R

机构：

[1] Univ Mons, Dept Biol Chem, B-7000 Mons, Belgium

[2] Univ Catholique Louvain, Sch Med, Unit Ind Toxicol & Occupat Med, B-1200 Brussels, Belgium

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 771卷 / 1-2期

关键词：

reviews; bronchoalveloar lavage; proteomics; proteins;

D O I：

10.1016/S1570-0232(02)00114-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Bronchoalveolar lavage during fiberoptic bronchoscopy is extensively used for investigating cellular and biochemical alterations of the epithelial lining fluid in various lung disorders. Two-dimensional electrophoresis (2-DE) offers the possibility to simultaneously display and analyze proteins contained in bronchoalveolar lavage fluid (BALF). We present the current status of 2-DE of BALF samples with an updated listing of the proteins already identified and of their level and/or posttranslational alterations in lung disorders. Alternatives to 2-DE of BALF samples and future prospects of proteomics to unravel lung functions and pathologies are discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：221 / 236

页数：16

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