Phenotype Standardization for Statin-Induced Myotoxicity

被引：176

作者：

Alfirevic, A. ^{[1
]}

Neely, D. ^{[2
]}

Armitage, J. ^{[3
]}

Chinoy, H. ^{[4
]}

Cooper, R. G. ^{[5
]}

Laaksonen, R. ^{[6
]}

Carr, D. F. ^{[1
]}

Bloch, K. M. ^{[1
]}

Fahy, J. ^{[1
]}

Hanson, A. ^{[1
]}

Yue, Q-Y ^{[7
]}

Wadelius, M. ^{[8
]}

Maitland-van der Zee, A. H. ^{[9
]}

Voora, D. ^{[10
]}

Psaty, B. M. ^{[11
,12
,13
]}

Palmer, C. N. A. ^{[14
]}

Pirmohamed, M. ^{[1
]}

机构：

[1] Univ Liverpool, Inst Translat Med, TheWolfson Ctr Personalised Med, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England

[2] Newcastle Upon Tyne Hosp NHS Fdn Trust, Royal Victoria Infirm, Dept Clin Biochem, Newcastle Upon Tyne, Tyne & Wear, England

[3] Clin Trial Serv Unit, Oxford, England

[4] Univ Manchester, NIHR Manchester Musculoskeletal Biomed Res Unit, Ctr Musculoskeletal Res, Manchester, Lancs, England

[5] Univ Liverpool, Fac Hlth & Life Sci, MRC ARUK Inst Ageing & Chron Dis, Liverpool L69 3BX, Merseyside, England

[6] Zora Biosci Ltd, Espoo, Finland

[7] Med Prod Agcy, Uppsala, Sweden

[8] Uppsala Univ, Clin Pharmacol & Sci Life Lab, Dept Med Sci, Uppsala, Sweden

[9] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Fac Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands

[10] Duke Inst Genome Sci & Policy, Durham, NC USA

[11] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[12] Univ Washington, Dept Epidemiol & Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA USA

[13] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA USA

[14] Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 9SY, Scotland

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2014年 / 96卷 / 04期

关键词：

INDUCED MYOPATHY; HOSPITALIZED RHABDOMYOLYSIS; PLASMA-CONCENTRATIONS; GENETIC VARIANT; GEMFIBROZIL; SIMVASTATIN; THERAPY; SLCO1B1; TRIALS; SAFETY;

D O I：

10.1038/clpt.2014.121

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

引用

页码：470 / 476

页数：7

共 70 条

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