5-Propynyluracil-diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

被引：20

作者：

Chaput, JC ^{[1
]}

Sinha, S ^{[1
]}

Switzer, C ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 15期

关键词：

D O I：

10.1039/b204535d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Up.D base-pair (5-propynyl uracil.diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T.A pair; under nonenzymatic reaction conditions where the natural T.A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.

引用

页码：1568 / 1569

页数：2

共 20 条

[1] AN INVERTED MOTIF FOR OLIGONUCLEOTIDE TRIPLEXES - ADENOSINE PSEUDOURIDINE ADENOSINE (A-PSI-A) [J].

BANDARU, R ;

HASHIMOTO, H ;

SWITZER, C .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (04) :786-787

[2] Long-range cooperativity in molecular recognition of RNA by oligodeoxynucleotides, with multiple C5-(1-propynyl) pyrimidines [J].

Barnes, TW ;

Turner, DH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (18) :4107-4118

[3] ORIGIN OF NATURALLY-OCCURRING ACETYLENES [J].

BULOCK, JD ;

SMITH, GN .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (05) :332-&

[4] Nonenzymatic oligomerization on templates containing phosphodiester-linked acyclic glycerol nucleic acid analogues [J].

Chaput, JC ;

Switzer, C .

JOURNAL OF MOLECULAR EVOLUTION, 2000, 51 (05) :464-470

[5] Non-enzymatic transcription of an IsoG•IsoC base pair [J].

Chaput, JC ;

Switzer, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (51) :12866-12867

[6] Synthesis of long prebiotic oligomers on mineral surfaces [J].

Ferris, JP ;

Hill, AR ;

Liu, RH ;

Orgel, LE .

NATURE, 1996, 381 (6577) :59-61

[7] The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes [J].

Freier, SM ;

Altmann, KH .

NUCLEIC ACIDS RESEARCH, 1997, 25 (22) :4429-4443

[8] OLIGONUCLEOTIDES DERIVED FROM 5-(1-PROPYNYL)-2'-O-ALLYL-URIDINE AND 5-(1-PROPYNYL)-2'-O-ALLYL-CYTIDINE - SYNTHESIS AND RNA DUPLEX FORMATION [J].

FROEHLER, BC ;

JONES, RJ ;

CAO, XD ;

TERHORST, TJ .

TETRAHEDRON LETTERS, 1993, 34 (06) :1003-1006

[9] Structure, energetics, and dynamics of the nucleic acid base pairs:: Nonempirical ab initio calculations [J].

Hobza, P ;

Sponer, J .

CHEMICAL REVIEWS, 1999, 99 (11) :3247-3276

[10] NON-ENZYMATIC TEMPLATE-DIRECTED SYNTHESIS ON RNA RANDOM COPOLYMERS - POLY(C,U) TEMPLATES [J].

JOYCE, GF ;

INOUE, T ;

ORGEL, LE .

JOURNAL OF MOLECULAR BIOLOGY, 1984, 176 (02) :279-306

← 1 2 →