High frequency of altered HLA class I phenotypes in laryngeal carcinomas

被引:40
作者
Cabrera, T
Salinero, J
Fernandez, MA
Garrido, A
Esquivias, J
Garrido, F
机构
[1] Univ Granada, Hosp Univ Virgen Nieves, Dept Anal Clin, E-18014 Granada, Spain
[2] Univ Granada, Hosp Univ Virgen Nieves, Dept Otorrinolaringol, E-18014 Granada, Spain
[3] Univ Granada, Hosp Univ Virgen Nieves, Dept Anat Patol, E-18014 Granada, Spain
关键词
HLA; class I; phenotypes; larynx; carcinomas;
D O I
10.1016/S0198-8859(00)00097-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The exact frequency of HLA class I losses in human tumors is unknown. We have previously shown that primary breast and colorectal carcinomas frequently lose HLA class I molecules (88% and 73%, respectively). Now we report that this phenomenon is also a frequent event in laryngeal carcinomas. Of a total of 76 laryngeal carcinomas analyzed, 66% of the tumors showed an alteration in HLA class I phenotype. These altered HLA phenotypes were classified as total HLA loss (10.52%) (phenotype I); HLA-A locus-specific loss (13.15%) (phenotype IIIa); HLA-B locus-specific loss (10.52%) (phenotype IIIb); HLA allelic loss (27.63%) (phenotype IV); and HLA-A and B locus loss (3.9%). Comparison of histopathological parameters with HLA expression showed that poorly differentiated tumors had the lowest levels of HLA class I expression (p < 0.05). Human Immunology 61, 499-506 (2000). (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.
引用
收藏
页码:499 / 506
页数:8
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