β2-integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10

被引:33
作者
Turunen, M
Wehlin, L
Sjöberg, M
Lundahl, J
Dallner, G [1 ]
Brismar, K
Sindelar, PJ
机构
[1] Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden
[2] Karolinska Inst, Karolinska Hosp, Dept Med, Div Clin Immunol & Allergy, S-10401 Stockholm, Sweden
[3] Karolinska Inst, Karolinska Hosp, Dept Mol Med, Div Endocrinol & Diabet, S-10401 Stockholm, Sweden
关键词
blood monocytes; coenzyme Q; alpha-tocopherol; antioxidants; beta; 2-integrins; arachidonic acid; plasmalogens atherosclerosis;
D O I
10.1016/S0006-291X(02)00871-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dietary supplementation with coenzyme Q (CoQ) has been proposed to have anti-atherogenic effects by virtue of its antioxidant capacity, To investigate this question, the leukocyte status of 5 males and 5 females (52-68 years) was evaluated before and after supplementation with 200mg CoQ/day for 5 and 10 weeks. CoQ was selectively taken up by mononuclear cells and alpha-tocopherol increased in polynuclear and mononuclear cells, The expression of beta2-integrin CD11b and complement receptor CD35 on the plasma membrane of resting and stimulated monocytes was significantly decreased upon dietary CoQ. Fatty acid and aldehyde analysis revealed that there was a selective increase of arachidonic acid and plasmalogens in only mononuclear cells. These selective lipid changes are not consistent with a general improvement in antioxidant status and indicate that CoQ most likely inhibits a phospholipase A,. Thus. these results strongly suggest that the anti-atherogenic effects of CoQ be mediated by other mechanisms beside its antioxidant protection. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:255 / 260
页数:6
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