The Epstein-Barr virus immediate-early protein BZLF1 induces both a G2 and a mitotic block

被引：35

作者：

Mauser, A

Holley-Guthrie, E

Simpson, D

Kaufmann, W

Kenney, S ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Pathol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 19期

关键词：

D O I：

10.1128/JVI.76.19.10030-10037.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Epstein-Barr virus immediate-early protein BZLF1 is a transcriptional activator that mediates the switch from latent to lytic infection. Here we demonstrate that BZLF1 induces both a G, block and a mitotic block in HeLa cells and inhibits chromosome condensation. While the G, block is associated with decreased cyclin B1 in host cells and can be rescued by overexpression of cyclin B1, the mechanism for the mitotic defect is as yet undetermined.

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页码：10030 / 10037

页数：8

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共 48 条

[1] The disappearance of cyclins A and B and the increase in activity of the G2/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the α22/US1.5 and UL13 viral genes [J].

Advani, SJ ;

Brandimarti, R ;

Weichselbaum, RR ;

Roizman, B .

JOURNAL OF VIROLOGY, 2000, 74 (01) :8-15

[2]

[Anonymous], 1996, Fields virology

[3]

[Anonymous], BIOCHIMICA BIOPHYSIC

[4] Role of human cytomegalovirus immediate-early proteins in cell growth control [J].

Castillo, JP ;

Yurochko, AD ;

Kowalik, TF .

JOURNAL OF VIROLOGY, 2000, 74 (17) :8028-8037

[5] G(0)/G(1), growth arrest mediated by a region encompassing the basic leucine zipper (bZIP) domain of the Epstein-Barr virus transactivator Zta [J].

Cayrol, C ;

Flemington, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (50) :31799-31802

[6] The Epstein-Barr virus bZIP transcription factor Zta causes G(0)/G(1) cell cycle arrest through induction of cyclin-dependent kinase inhibitors [J].

Cayrol, C ;

Flemington, EK .

EMBO JOURNAL, 1996, 15 (11) :2748-2759

[7] BOTH EPSTEIN-BARR-VIRUS (EBV)-ENCODED TRANS-ACTING FACTORS, EB1 AND EB2, ARE REQUIRED TO ACTIVATE TRANSCRIPTION FROM AN EBV EARLY PROMOTER [J].

CHEVALLIERGRECO, A ;

MANET, E ;

CHAVRIER, P ;

MOSNIER, C ;

DAILLIE, J ;

SERGEANT, A .

EMBO JOURNAL, 1986, 5 (12) :3243-3249

[8] INHIBITORY EFFECT OF DIHYDROXYACETONE ON GLUCONOBACTER-OXYDANS - KINETIC ASPECTS AND EXPRESSION BY MATHEMATICAL EQUATIONS [J].

CLARET, C ;

BORIES, A ;

SOUCAILLE, P .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1993, 11 (02) :105-112

[9] ACTIVATION OF EXPRESSION OF LATENT EPSTEIN-BARR HERPESVIRUS AFTER GENE-TRANSFER WITH A SMALL CLONED SUBFRAGMENT OF HETEROGENEOUS VIRAL-DNA [J].

COUNTRYMAN, J ;

MILLER, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) :4085-4089

[10] Human cytomegalovirus infection inhibits G(1)/S transition [J].

Dittmer, D ;

Mocarski, ES .

JOURNAL OF VIROLOGY, 1997, 71 (02) :1629-1634

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