The Epstein-Barr virus immediate-early protein BZLF1 induces both a G2 and a mitotic block

被引：35

作者：

Mauser, A

Holley-Guthrie, E

Simpson, D

Kaufmann, W

Kenney, S ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Pathol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 19期

关键词：

D O I：

10.1128/JVI.76.19.10030-10037.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Epstein-Barr virus immediate-early protein BZLF1 is a transcriptional activator that mediates the switch from latent to lytic infection. Here we demonstrate that BZLF1 induces both a G, block and a mitotic block in HeLa cells and inhibits chromosome condensation. While the G, block is associated with decreased cyclin B1 in host cells and can be rescued by overexpression of cyclin B1, the mechanism for the mitotic defect is as yet undetermined.

引用

收藏

页码：10030 / 10037

页数：8

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