Protein misfolding and aggregation are associated with more than twenty diseases, such as neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may induce cell membrane disruption and lead to cell apoptosis. A great number of studies have focused on discovery of amyloid inhibitors which may prevent or treat amyloidosis diseases. Polyphenols have been extensively studied as a class of amyloid inhibitors, with several polyphenols under clinical trials as anti-neurodegenerative drugs. As oxidative intermediates of natural polyphenols, quinones widely exist in medicinal plants or food. In this study, we used insulin as an amyloid model to test the anti-amyloid effects of four simple quinones and four natural anthraquinone derivatives from rhubarb, a traditional herbal medicine used for treating Alzheimer's disease. Our results demonstrated that all eight quinones show inhibitory effects to different extent on insulin oligomerization, especially for 1,4-benzoquinone and 1,4-naphthoquinone. Significantly attenuated oligomerization, reduced amount of amyloid fibrils and reduced hemolysis levels were found after quinones treatments, indicating quinones may inhibit insulin from forming toxic oligomeric species. The results suggest a potential action of native anthraquinone derivatives in preventing protein misfolding diseases, the quinone skeleton may thus be further explored for designing effective anti-amyloidosis compounds.
机构:
Department of Biophysics, School of Medicine, Saarland University
Faculty of Agriculture, Goce Delčev University, ŠtipDepartment of Biophysics, School of Medicine, Saarland University
Gulaboski R.
Bogeski I.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Bogeski I.
Mirčeski V.
论文数: 0引用数: 0
h-index: 0
机构:
Institute of Chemistry, Faculty of Natural Sciences and Mathematics, SS Cyril and Methodius University, SkopjeDepartment of Biophysics, School of Medicine, Saarland University
Mirčeski V.
Saul S.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Saul S.
Pasieka B.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Pasieka B.
Haeri H.H.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Haeri H.H.
论文数: 引用数:
h-index:
机构:
Stefova M.
论文数: 引用数:
h-index:
机构:
Stanoeva J.P.
Mitrev S.
论文数: 0引用数: 0
h-index: 0
机构:
Faculty of Agriculture, Goce Delčev University, ŠtipDepartment of Biophysics, School of Medicine, Saarland University
Mitrev S.
Hoth M.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Hoth M.
Kappl R.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Hindo, Sarmad S.
Mancino, Allana M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Mancino, Allana M.
Braymer, Joseph J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Braymer, Joseph J.
Liu, Yihong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Liu, Yihong
Vivekanandan, Subramanian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Vivekanandan, Subramanian
Ramamoorthy, Ayyalusamy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Ramamoorthy, Ayyalusamy
Lim, Mi Hee
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
DeToma, Alaina S.
Brender, Jeffrey R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Brender, Jeffrey R.
Lee, Sanghyun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Lee, Sanghyun
Vivekanandan, Subramanian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Vivekanandan, Subramanian
Kochi, Akiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Kochi, Akiko
Choi, Jung-Suk
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Choi, Jung-Suk
Ramamoorthy, Ayyalusamy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Ramamoorthy, Ayyalusamy
Ruotolo, Brandon T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Ruotolo, Brandon T.
Lim, Mi Hee
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Kim, Jihoon
Kobayashi, Masaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Kobayashi, Masaki
Fukuda, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Fukuda, Makoto
Ogasawara, Daisuke
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Ogasawara, Daisuke
Kobayashi, Natsuki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Kobayashi, Natsuki
Han, Sungwoong
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Natl Inst Adv Ind Sci & Technol, Res Inst Cell Engn, Koto Ku, Tokyo, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Han, Sungwoong
Nakamura, Chikashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Natl Inst Adv Ind Sci & Technol, Res Inst Cell Engn, Koto Ku, Tokyo, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Nakamura, Chikashi
Inada, Masaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Inada, Masaki
Miyaura, Chisato
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Miyaura, Chisato
Ikebukuro, Kazunori
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
机构:
Department of Biophysics, School of Medicine, Saarland University
Faculty of Agriculture, Goce Delčev University, ŠtipDepartment of Biophysics, School of Medicine, Saarland University
Gulaboski R.
Bogeski I.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Bogeski I.
Mirčeski V.
论文数: 0引用数: 0
h-index: 0
机构:
Institute of Chemistry, Faculty of Natural Sciences and Mathematics, SS Cyril and Methodius University, SkopjeDepartment of Biophysics, School of Medicine, Saarland University
Mirčeski V.
Saul S.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Saul S.
Pasieka B.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Pasieka B.
Haeri H.H.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Haeri H.H.
论文数: 引用数:
h-index:
机构:
Stefova M.
论文数: 引用数:
h-index:
机构:
Stanoeva J.P.
Mitrev S.
论文数: 0引用数: 0
h-index: 0
机构:
Faculty of Agriculture, Goce Delčev University, ŠtipDepartment of Biophysics, School of Medicine, Saarland University
Mitrev S.
Hoth M.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
Hoth M.
Kappl R.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Biophysics, School of Medicine, Saarland UniversityDepartment of Biophysics, School of Medicine, Saarland University
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Hindo, Sarmad S.
Mancino, Allana M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Mancino, Allana M.
Braymer, Joseph J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Braymer, Joseph J.
Liu, Yihong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Liu, Yihong
Vivekanandan, Subramanian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Vivekanandan, Subramanian
Ramamoorthy, Ayyalusamy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
Ramamoorthy, Ayyalusamy
Lim, Mi Hee
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Biophys & Dept Chem, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
DeToma, Alaina S.
Brender, Jeffrey R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Brender, Jeffrey R.
Lee, Sanghyun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Lee, Sanghyun
Vivekanandan, Subramanian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Vivekanandan, Subramanian
Kochi, Akiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Kochi, Akiko
Choi, Jung-Suk
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Choi, Jung-Suk
Ramamoorthy, Ayyalusamy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Ramamoorthy, Ayyalusamy
Ruotolo, Brandon T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Ruotolo, Brandon T.
Lim, Mi Hee
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem, Ann Arbor, MI 48109 USA
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Kim, Jihoon
Kobayashi, Masaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Kobayashi, Masaki
Fukuda, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Fukuda, Makoto
Ogasawara, Daisuke
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Ogasawara, Daisuke
Kobayashi, Natsuki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Kobayashi, Natsuki
Han, Sungwoong
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Natl Inst Adv Ind Sci & Technol, Res Inst Cell Engn, Koto Ku, Tokyo, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Han, Sungwoong
Nakamura, Chikashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Natl Inst Adv Ind Sci & Technol, Res Inst Cell Engn, Koto Ku, Tokyo, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Nakamura, Chikashi
Inada, Masaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Inada, Masaki
Miyaura, Chisato
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan
Miyaura, Chisato
Ikebukuro, Kazunori
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, JapanTokyo Univ Agr & Technol, Dept Biotechnol, Grad Sch Engn, Koganei, Tokyo 184, Japan