Early perceptual anomaly of negative facial expression in depression: An event-related potential study

被引:43
作者
Zhao, Q. [1 ]
Tang, Y. [2 ,3 ]
Chen, S. [1 ]
Lyu, Y. [1 ]
Curtin, A. [1 ]
Wang, J. [2 ,3 ]
Sun, J. [1 ]
Tong, S. [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept EEG Source Imaging, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China
来源
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY | 2015年 / 45卷 / 06期
基金
中国国家自然科学基金;
关键词
Depression; Negative cognitive bias; ERP; P1; N170; EMOTIONAL STIMULI; FACE PERCEPTION; ATTENTION;
D O I
10.1016/j.neucli.2015.09.011
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Depressed patients have a demonstrated cognitive bias in emotional information processing. However, it is unknown how early perceptual processing is modulated by emotional stimuli in depression. To examine this question, we studied 22 depressed patients and 22 healthy controls performing a cued target-response task with emotional facial expression as the cue. The early perceptual processes were examined using event-related potential (ERP) components, i.e., P1 and N170. Results showed that depressed patients had larger P1 amplitudes than healthy controls, implying that early perceptual abnormality for face processing in depression may occur as early as the P1 stage. There was no significant interaction between emotion types and groups on P1 amplitudes, which suggested that cognitive biases in depression might not yet have arisen. Following the P1 stage, N170 amplitudes for sad faces were larger than for other emotion types in depressed patients, whereas N170 amplitudes for happy faces were larger than for other emotion types in healthy controls. These results implied that depressed patients might have a perceptual bias associated with sad emotions, which may be detectable from the N170 time window. In summary, this study provides new insights for understanding the negative cognitive bias in depression using the electroneurophysiological biomarker N170. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:435 / 443
页数:9
相关论文
共 34 条
[1]
[Anonymous], 1994, DIAGN STAT MAN MENT, Vfourth
[2]
Early processing of the six basic facial emotional expressions [J].
Batty, M ;
Taylor, MJ .
COGNITIVE BRAIN RESEARCH, 2003, 17 (03) :613-620
[3]
BECK A., 1979, Cognitive Therapy of Anxiety and Phobic Disorders
[4]
Electrophysiological studies of face perception in humans [J].
Bentin, S ;
Allison, T ;
Puce, A ;
Perez, E ;
McCarthy, G .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1996, 8 (06) :551-565
[5]
Mood effects on the ERP processing of emotional intensity in faces: A P3 investigation with depressed students [J].
Cavanagh, J ;
Geisler, MW .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2006, 60 (01) :27-33
[6]
Chen S, 2012, IEEE ENG MED BIO, P6776, DOI 10.1109/EMBC.2012.6347550
[7]
More excited for negative facial expressions in depression: Evidence from an event-related potential study [J].
Dai, Qin ;
Feng, Zhengzhi .
CLINICAL NEUROPHYSIOLOGY, 2012, 123 (11) :2172-2179
[8]
Deficient distracter inhibition and enhanced facilitation for emotional stimuli in depression: An ERP study [J].
Dai, Qin ;
Feng, Zhengzhi ;
Koster, Ernst H. W. .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2011, 79 (02) :249-258
[9]
Deficient inhibition of return for emotional faces in depression [J].
Dai, Qin ;
Feng, Zhengzhi .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (06) :921-932
[10]
Right-posterior face processing anomaly in depression [J].
Deldin, PJ ;
Keller, J ;
Gergen, JA ;
Miller, GA .
JOURNAL OF ABNORMAL PSYCHOLOGY, 2000, 109 (01) :116-121