Catalytic synthesis of aldehydes and ketones under mild conditions using TEMPO/Oxone

被引：205

作者：

Bolm, C ^{[1
]}

Magnus, AS ^{[1
]}

Hildebrand, JP ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 08期

关键词：

D O I：

10.1021/ol005792g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, metal-free oxidation system for the catalytic synthesis of aldehydes and ketones-TEMPO/Oxone-has been developed. An optimized reaction protocol proved especially successful for the synthesis of ketones. Additionally, the influence of quarternary ammonium salts on the catalysis was studied. The mild conditions of this novel procedure were shown to tolerate even sensitive silyl protective groups which can otherwise be cleaved in the presence of Oxone.

引用

页码：1173 / 1175

页数：3

共 32 条

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