The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

被引：3393

作者：

Vardiman, James W. ^{[1
]}

Thiele, Juergen ^{[2
]}

Arber, Daniel A. ^{[3
]}

Brunning, Richard D. ^{[4
]}

Borowitz, Michael J. ^{[5
]}

Porwit, Anna ^{[6
]}

Harris, Nancy Lee ^{[7
,8
]}

Le Beau, Michelle M. ^{[9
]}

Hellstrom-Lindberg, Eva ^{[10
]}

Tefferi, Ayalew ^{[11
]}

Bloomfield, Clara D. ^{[12
]}

机构：

[1] Univ Chicago Hosp, Dept Pathol, Chicago, IL 60637 USA

[2] Univ Cologne, Inst Pathol, D-5000 Cologne, Germany

[3] Stanford Univ, Dept Pathol, Med Ctr, Stanford, CA 94305 USA

[4] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[5] Johns Hopkins Med Inst, Dept Pathol & Oncol, Baltimore, MD 21205 USA

[6] Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden

[7] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[8] Harvard Univ, Sch Med, Boston, MA USA

[9] Univ Chicago Hosp, Hematol Oncol Sect, Chicago, IL 60637 USA

[10] Karolinska Univ Hosp, Dept Med, Stockholm, Sweden

[11] Mayo Clin, Div Hematol, Rochester, MN USA

[12] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

BLOOD | 2009年 / 114卷 / 05期

关键词：

BALANCED CHROMOSOME-ABERRATIONS; CHRONIC MYELOMONOCYTIC LEUKEMIA; ACQUIRED APLASTIC-ANEMIA; TRANSIENT MYELOPROLIFERATIVE DISORDER; INDEPENDENT PROGNOSTIC RELEVANCE; ACUTE LYMPHOBLASTIC-LEUKEMIA; TYROSINE KINASE JAK2; BONE-MARROW BIOPSY; MYELODYSPLASTIC SYNDROMES; ESSENTIAL THROMBOCYTHEMIA;

D O I：

10.1182/blood-2009-03-209262

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities-some defined principally by genetic features-that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes. (Blood. 2009; 114: 937-951)

引用

页码：937 / 951

页数：15

共 121 条

[71] Hypoplastic myelodysplastic syndromes can be distinguished from acquired aplastic anemia by CD34 and PCNA immunostaining of bone marrow biopsy specimens [J].

Orazi, A ;

Albitar, M ;

Heerema, NA ;

Haskins, S ;

Neiman, RS .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1997, 107 (03) :268-274

[72]

PADUA RA, 1988, LEUKEMIA, V2, P503

[73] Biologic heterogeneity in Philadelphia chromosome-positive acute leukemia with myeloid morphology: the Eastern Cooperative Oncology Group experience [J].

Paietta, E ;

Racevskis, J ;

Bennett, JM ;

Neuberg, D ;

Cassileth, PA ;

Rowe, JM ;

Wiernik, PH .

LEUKEMIA, 1998, 12 (12) :1881-1885

[74] Pathogenesis, clinical features, and treatment advances in mastocytosis [J].

Pardanani, A. ;

Akin, C. ;

Valent, P. .

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2006, 19 (03) :595-615

[75] MPL515 mutations in myeloproliferative and other myeloid disorders:: a study of 1182 patients [J].

Pardanani, Animesh D. ;

Levine, Ross L. ;

Lasho, Terra ;

Pikman, Yana ;

Mesa, Ruben A. ;

Wadleigh, Martha ;

Steensma, David P. ;

Elliott, Michelle A. ;

Wolanskyj, Alexandra R. ;

Hogan, William J. ;

McClure, Rebecca F. ;

Litzow, Mark R. ;

Gilliland, D. Gary ;

Tefferi, Ayalew .

BLOOD, 2006, 108 (10) :3472-3476

[76] Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21):: A Cancer and Leukemia Group B study [J].

Paschka, Peter ;

Marcucci, Guido ;

Ruppert, Amy S. ;

Mrozek, Krzysztof ;

Chen, Hankui ;

Kittles, Rick A. ;

Vukosavljevic, Tamara ;

Perrotti, Danilo ;

Vardiman, James W. ;

Carroll, Andrew J. ;

Kolitz, Jonathan E. ;

Larson, Richard A. ;

Bloomfield, Clara D. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (24) :3904-3911

[77] INCREASED NUMBERS OF MARROW BASOPHILS MAY BE ASSOCIATED WITH A T(6-9) IN ANLL [J].

PEARSON, MG ;

VARDIMAN, JW ;

LEBEAU, MM ;

ROWLEY, JD ;

SCHWARTZ, S ;

KERMAN, SL ;

COHEN, MM ;

FLEISCHMAN, EW ;

PRIGOGINA, EL .

AMERICAN JOURNAL OF HEMATOLOGY, 1985, 18 (04) :393-403

[78] 'Agranular CD4+CD56+hematodermic neoplasm' (blastic NK-cell lymphoma) originates from a population of CD56+precursor cells related to plasmacytoid monocytes [J].

Petrella, T ;

Comeau, MR ;

Maynadié, M ;

Couillault, G ;

De Muret, A ;

Maliszewski, CR ;

Dalac, S ;

Durlach, A ;

Galibert, L .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (07) :852-862

[79]

PIERRE RV, 1972, CANCER, V30, P889, DOI 10.1002/1097-0142(197210)30:4<889::AID-CNCR2820300405>3.0.CO

[80]

2-1

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