What can information-asymmetric games tell us about the context of Crick's 'frozen accident'?
被引:11
作者:
Jee, Justin
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NYU, Courant Inst Math Sci, New York, NY 10003 USA
NYU, Sackler Inst Biomed Sci, New York, NY 10016 USANYU, Courant Inst Math Sci, New York, NY 10003 USA
Jee, Justin
[1
,2
]
Sundstrom, Andrew
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NYU, Courant Inst Math Sci, New York, NY 10003 USANYU, Courant Inst Math Sci, New York, NY 10003 USA
Sundstrom, Andrew
[1
]
Massey, Steven E.
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Univ Puerto Rico Rio Piedras, Dept Biol, San Juan, PR 00931 USANYU, Courant Inst Math Sci, New York, NY 10003 USA
Massey, Steven E.
[3
]
Mishra, Bud
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NYU, Courant Inst Math Sci, New York, NY 10003 USA
NYU, Sackler Inst Biomed Sci, New York, NY 10016 USANYU, Courant Inst Math Sci, New York, NY 10003 USA
Mishra, Bud
[1
,2
]
机构:
[1] NYU, Courant Inst Math Sci, New York, NY 10003 USA
[2] NYU, Sackler Inst Biomed Sci, New York, NY 10016 USA
[3] Univ Puerto Rico Rio Piedras, Dept Biol, San Juan, PR 00931 USA
This paper describes a novel application of information-asymmetric (signalling) games to molecular biology in which utility is determined by the message complexity (rate) in addition to the error in information transfer (distortion). We show using a computational model how it is possible for the agents in one such game to evolve a signalling convention (separating equilibrium) that is suboptimal in terms of information transfer, but is nonetheless stable. In the context of an RNA world merging with a nascent amino acid one, such a game's equilibrium is alluded to by the genetic code, which is nearly optimal in terms of information transfer, but is also near-universal and nearly immutable. Such a framework suggests that cellularity may have emerged to encourage coordination between RNA species and sheds light on other aspects of RNA world biochemistry yet to be fully understood.
Fisher R. A., 1922, Proceedings of the Royal Society of Edinburgh, V42, P321, DOI [DOI 10.1017/S0370164600023993, https://doi.org/10.1017/S0370164600023993]
Fisher R. A., 1922, Proceedings of the Royal Society of Edinburgh, V42, P321, DOI [DOI 10.1017/S0370164600023993, https://doi.org/10.1017/S0370164600023993]