What can information-asymmetric games tell us about the context of Crick's 'frozen accident'?

被引:11
作者
Jee, Justin [1 ,2 ]
Sundstrom, Andrew [1 ]
Massey, Steven E. [3 ]
Mishra, Bud [1 ,2 ]
机构
[1] NYU, Courant Inst Math Sci, New York, NY 10003 USA
[2] NYU, Sackler Inst Biomed Sci, New York, NY 10016 USA
[3] Univ Puerto Rico Rio Piedras, Dept Biol, San Juan, PR 00931 USA
关键词
information-asymmetric games; signalling; genetic code; RNA world; GENETIC-CODE; ARBITRARY SEQUENCE; EVOLUTION; CHROMODYNAMICS; POPULATIONS; ORIGIN;
D O I
10.1098/rsif.2013.0614
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
This paper describes a novel application of information-asymmetric (signalling) games to molecular biology in which utility is determined by the message complexity (rate) in addition to the error in information transfer (distortion). We show using a computational model how it is possible for the agents in one such game to evolve a signalling convention (separating equilibrium) that is suboptimal in terms of information transfer, but is nonetheless stable. In the context of an RNA world merging with a nascent amino acid one, such a game's equilibrium is alluded to by the genetic code, which is nearly optimal in terms of information transfer, but is also near-universal and nearly immutable. Such a framework suggests that cellularity may have emerged to encourage coordination between RNA species and sheds light on other aspects of RNA world biochemistry yet to be fully understood.
引用
收藏
页数:8
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