Targeting events in melanoma carcinogenesis for the prevention of melanoma

被引:54
作者
Lao, Christopher D.
Demierre, Marie-France
Sondok, Vernon K.
机构
[1] Univ Michigan, Ann Arbor, MI 48109 USA
[2] Boston Univ, Sch Med, Boston, MA 02118 USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Interdisciplinary Oncol & Surg, Tampa, FL USA
[4] H Lee Moffitt Canc Ctr & Res Inst, Div Cutaneous Oncol, Tampa, FL USA
[5] Univ S Florida, Coll Med, Dept Interdisciplinary Oncol & Surg, Tampa, FL USA
关键词
chemoprevention; curcumin; green tea; melanoma; resveratrol; silymarin; statins;
D O I
10.1586/14737140.6.11.1559
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Melanoma is one of the few tumors that have increased in incidence over the last few decades. Strategies devoted solely to protecting against ultraviolet radiation have, at best, had a modest impact on the development of melanoma. Chemoprevention is an under-explored approach that could significantly decrease the morbidity and mortality from this deadly cancer. However, the scientific and logistical challenges of performing clinical studies in chemoprevention require innovative approaches to prove the effectiveness of putative preventive agents. There are several pharmacological and nutriceutical agents that are mechanistically linked to events in melanoma carcinogenesis that are candidates for advanced human studies. We will review the data for several promising agents, including statins, curcumin, resveratrol, silymarin and green tea, and discuss some importance issues and concepts that should be considered in any melanoma chemoprevention strategy.
引用
收藏
页码:1559 / 1568
页数:10
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