Multimodal treatment of hepatocellular carcinoma

被引:110
作者
Graf, Dirk [1 ]
Vallboehmer, Daniel [2 ]
Knoefel, Wolfram Trudo [2 ]
Kroepil, Patric [3 ]
Antoch, Gerald [3 ]
Sagir, Abdurrahaman [1 ]
Haeussinger, Dieter [1 ]
机构
[1] Univ Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Fac Med, D-40225 Dusseldorf, Germany
[2] Univ Dusseldorf, Dept Gen Visceral & Pediat Surg, Fac Med, D-40225 Dusseldorf, Germany
[3] Univ Dusseldorf, Dept Diagnost & Intervent Radiol, Fac Med, D-40225 Dusseldorf, Germany
关键词
Hepatocellular carcinoma; Liver transplantation; Radiofrequency ablation; Transarterial chemoembolization; Sorafenib; RANDOMIZED CONTROLLED-TRIAL; BODY RADIATION-THERAPY; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; RADIOFREQUENCY THERMAL ABLATION; DONOR LIVER-TRANSPLANTATION; PORTAL-VEIN LIGATION; TRANSARTERIAL CHEMOEMBOLIZATION; ETHANOL INJECTION; HEPATIC RESECTION; SURGICAL RESECTION;
D O I
10.1016/j.ejim.2014.03.001
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Hepatocellular carcinoma (HCC) represents the most common liver cancer with an increasing incidence and it accounts for the third most common cause of cancer-related death world wide. Even though the clinical diagnosis and management of HCC improved significantly in the last decades, this malignant disease is still associated with a poor prognosis. It has to be distinguished between patients with HCCs, which developed from liver cirrhosis, and patients without underlying liver cirrhosis as classification systems, prognosis estimation and therapy recommendations differ in-between. In case of HCC in patients with liver cirrhosis in Europe, treatment allocation and prognosis estimation are mainly based on the Barcelona-Clinic Liver Cancer (BCLC) staging system. Based on this staging system different surgical, interventional radiological/sonographical and non-interventional procedures have been established for the multimodal treatment of HCC. The BCLC classification system represents a decision guidance; however because of its limitations in selected patients treatment allocation should be determined on an individualized rather than a guideline-based medicine by a multidisciplinary board in order to offer the best treatment option for each patient. This review summarizes the current management of HCC and illustrates controversial areas of therapeutic strategies. (C) 2014 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:430 / 437
页数:8
相关论文
共 104 条
[81]
Phase II study of concurrent transarterial chemoembolization and sorafenib in patients with unresectable hepatocellular carcinoma [J].
Park, Joong-Won ;
Koh, Young Hwan ;
Kim, Hyun Beom ;
Kim, Hwi Young ;
An, Sangbu ;
Choi, Joon-Il ;
Woo, Sang Myung ;
Nam, Byung-Ho .
JOURNAL OF HEPATOLOGY, 2012, 56 (06) :1336-1342
[82]
Global cancer statistics, 2002 [J].
Parkin, DM ;
Bray, F ;
Ferlay, J ;
Pisani, P .
CA-A CANCER JOURNAL FOR CLINICIANS, 2005, 55 (02) :74-108
[83]
Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization:: a multicenter randomized trial [J].
Pelletier, G ;
Ducreux, M ;
Gay, F ;
Luboinski, M ;
Hagège, H ;
Dao, T ;
Van Steenbergen, W ;
Buffet, C ;
Rougier, P ;
Adler, M ;
Pignon, JP ;
Roche, A .
JOURNAL OF HEPATOLOGY, 1998, 29 (01) :129-134
[84]
Report of a National conference on Liver Allocation in Patients with Hepatocellular Carcinoma in the United States [J].
Pomfret, Elizabeth A. ;
Washburn, Kenneth ;
Wald, Christoph ;
Nalesnik, Michael A. ;
Douglas, David ;
Russo, Mark ;
Roberts, John ;
Reich, David J. ;
Schwartz, Myron E. ;
Mieles, Luis ;
Lee, Fred T. ;
Florman, Sander ;
Yao, Francis ;
Harper, Ann ;
Edwards, Erick ;
Freeman, Richard ;
Lake, John .
LIVER TRANSPLANTATION, 2010, 16 (03) :262-278
[85]
Pons Fernando, 2005, HPB (Oxford), V7, P35, DOI 10.1080/13651820410024058
[86]
Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter [J].
Poon, RTP ;
Fan, ST ;
Wong, J .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2002, 194 (05) :592-602
[87]
Radeleff BA, 2012, RADIOLOGE, V52, P44, DOI 10.1007/s00117-011-2211-1
[88]
RAIA S, 1989, LANCET, V2, P497
[89]
Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: Available evidence and expert opinion on the use of transarterial chemoembolization [J].
Raoul, J. -L. ;
Sangro, B. ;
Forner, A. ;
Mazzaferro, V. ;
Piscaglia, F. ;
Bolondi, L. ;
Lencioni, R. .
CANCER TREATMENT REVIEWS, 2011, 37 (03) :212-220
[90]
SURGICAL-TREATMENT OF HEPATOCELLULAR-CARCINOMA - EXPERIENCE WITH LIVER RESECTION AND TRANSPLANTATION IN 198 PATIENTS [J].
RINGE, B ;
PICHLMAYR, R ;
WITTEKIND, C ;
TUSCH, G .
WORLD JOURNAL OF SURGERY, 1991, 15 (02) :270-285