Isotype-specific functions of Raf kinases

被引:216
作者
Hagemann, C [1 ]
Rapp, UR [1 ]
机构
[1] Inst Med Strahlenkunde & Zellforsch, D-97078 Wurzburg, Germany
关键词
Raf; signal-transduction; interaction partner; specificity;
D O I
10.1006/excr.1999.4689
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The family of Raf-protein kinases consisting of A-Raf, B-Raf, and c-Raf-1 is involved in cellular processes which regulate proliferation, differentiation, and apoptosis. Cell-culture experiments and the knockout of individual Raf genes suggested that the three Raf isoforms have overlapping and unique regulatory functions. However, it is not known how these isotype-specific functions of Raf kinases occur in the cell. Published data suggest that Raf proteins might differ in the regulation of their activation as well as in their ability to connect to downstream signaling pathways. Since Raf is part of a multiprotein complex and protein-protein interactions are important for Raf signaling, we propose that isotype-specific functions can be achieved by isotype-restricted protein binding. Recently we were able to identify candidates for such Raf-isoform-specific interaction partners.
引用
收藏
页码:34 / 46
页数:13
相关论文
共 113 条
  • [31] Organization and regulation of mitogen-activated protein kinase signaling pathways
    Garrington, TP
    Johnson, GL
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) : 211 - 218
  • [32] TC21 and Ras share indistinguishable transforming and differentiating activities
    Graham, SM
    Oldham, SM
    Martin, CB
    Drugan, JK
    Zohn, IE
    Campbell, S
    Der, CJ
    [J]. ONCOGENE, 1999, 18 (12) : 2107 - 2116
  • [33] Proteasomes play an essential role in thymocyte apoptosis
    Grimm, LM
    Goldberg, AL
    Poirier, GG
    Schwartz, LM
    Osborne, BA
    [J]. EMBO JOURNAL, 1996, 15 (15) : 3835 - 3844
  • [34] A role for the proteasome regulator PA28 alpha in antigen presentation
    Groettrup, M
    Soza, A
    Eggers, M
    Kuehn, L
    Dick, TP
    Schild, H
    Rammensee, HG
    Koszinowski, UH
    Kloetzel, PM
    [J]. NATURE, 1996, 381 (6578) : 166 - 168
  • [35] The regulatory subunit of protein kinase CK2 is a specific A-Raf activator
    Hagemann, C
    Kalmes, A
    Wixler, V
    Wixler, L
    Schuster, T
    Rapp, UR
    [J]. FEBS LETTERS, 1997, 403 (02) : 200 - 202
  • [36] Regulation of protein phosphatase 2A by direct interaction with casein kinase 2 alpha
    Heriche, JK
    Lebrin, F
    Rabilloud, T
    Leroy, D
    Chambaz, EM
    Goldberg, Y
    [J]. SCIENCE, 1997, 276 (5314) : 952 - 955
  • [37] MAP KINASE PATHWAYS IN YEAST - FOR MATING AND MORE
    HERSKOWITZ, I
    [J]. CELL, 1995, 80 (02) : 187 - 197
  • [38] Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with Ras-dependent activation of Raf-1
    Hu, CD
    Kariya, K
    Kotani, G
    Shirouzu, M
    Yokoyama, S
    Kataoka, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (18) : 11702 - 11705
  • [39] STIMULATORY EFFECTS OF YEAST AND MAMMALIAN 14-3-3-PROTEINS ON THE RAF PROTEIN-KINASE
    IRIE, K
    GOTOH, Y
    YASHAR, BM
    ERREDE, B
    NISHIDA, E
    MATSUMOTO, K
    [J]. SCIENCE, 1994, 265 (5179) : 1716 - 1719
  • [40] CASEIN KINASES - PLEIOTROPIC MEDIATORS OF CELLULAR-REGULATION
    ISSINGER, OG
    [J]. PHARMACOLOGY & THERAPEUTICS, 1993, 59 (01) : 1 - 30