RETRACTED: Severe Dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy") (Retracted Article)

被引：117

作者：

Ricaurte, GA ^{[1
]}

Yuan, J

Hatzidimitriou, G

Cord, BJ

McCann, UD

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Johns Hopkins Bayview Med Ctr, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Johns Hopkins Bayview Med Ctr, Baltimore, MD 21224 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat, Johns Hopkins Bayview Med Ctr, Baltimore, MD 21224 USA

来源：

SCIENCE | 2002年 / 297卷 / 5590期

关键词：

D O I：

10.1126/science.1074501

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The prevailing view is that the popular recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary to dopamine depletion. These results have implications for mechanisms of MDMA neurotoxicity and suggest that recreational MDMA users may unwittingly be putting themselves at risk, either as young adults or later in life, for developing neuropsychiatric disorders related to brain dopamine and/or serotonin deficiency.

引用

页码：2260 / 2263

页数：5

共 32 条

[21] Memory deficits associated with recreational use of "ecstasy" (MDMA) [J].