Cells on chips

被引：1717

作者：

El-Ali, Jamil

Sorger, Peter K.

Jensen, Klavs F.

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Biol & Biol Engn, Ctr Cell Decis Proc, Cambridge, MA 02139 USA

来源：

NATURE | 2006年 / 442卷 / 7101期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature05063

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microsystems create new opportunities for the spatial and temporal control of cell growth and stimuli by combining surfaces that mimic complex biochemistries and geometries of the extracellular matrix with microfluidic channels that regulate transport of fluids and soluble factors. Further integration with bioanalytic microsystems results in multifunctional platforms for basic biological insights into cells and tissues, as well as for cell-based sensors with biochemical, biomedical and environmental functions. Highly integrated microdevices show great promise for basic biomedical and pharmaceutical research, and robust and portable point-of-care devices could be used in clinical settings, in both the developed and the developing world.

引用

页码：403 / 411

页数：9

共 104 条

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