Immunization with a DNA expression vector encoding the varicella tester virus glycoprotein E (gE) gene via intramuscular and subcutaneous routes

被引：14

作者：

Hasan, UA

Harper, DR

Argent, S

Layton, G

Wren, BW

Morrow, WJW

机构：

[1] St Bartholomews & Royal London Sch Med & Dent, Dept Immunol, London EC1A 7BE, England

[2] St Bartholomews & Royal London Sch Med & Dent, Dept Med Microbiol, London EC1A 7BE, England

[3] British Biotech Pharmaceut Ltd, Oxford, England

来源：

VACCINE | 2000年 / 18卷 / 15期

关键词：

nucleic acid immunization; chickenpox; shingles; human herpes virus 3;

D O I：

10.1016/S0264-410X(99)00428-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we constructed a plasmid containing the gene encoding varicella-zoster virus transmembrane glycoprotein gE (VZV gE) and evaluated its utility for DNA immunization in mice. Our initial work demonstrates that intramuscular and subcutaneous injection of VZV gE DNA, without the use of costimulatory molecules or other adjuvant materials, results in the generation of antigen-specific antibodies of primarily the IgG2a subclass, indicating that this vaccine can stimulate Th1 type immunity. This is the first report of a prototype DNA vaccine for varicella-zoster virus. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1506 / 1514

页数：9