CD4+ and CD8+ T lymphocyte regeneration after anti-retroviral therapy in HIV-1-infected children and adult patients

被引:51
作者
Franco, JM
León-Leal, JA
Leal, M
Cano-Rodriguez, A
Pineda, JA
Macías, J
Rubio, R
Rey, C
Sanchez, B
Lissen, E
机构
[1] Virgen Rocio Univ Hosp, Viral Hepatitis & AIDS Study Grp, E-41013 Seville, Spain
[2] Virgen Rocio Univ Hosp, Dept Paediat, E-41013 Seville, Spain
[3] Virgen Rocio Univ Hosp, Dept Radiol, E-41013 Seville, Spain
[4] Virgen Rocio Univ Hosp, Dept Biochem, E-41013 Seville, Spain
[5] Virgen Rocio Univ Hosp, Dept Immunol, E-41013 Seville, Spain
关键词
anti-retroviral therapy; immune reconstitution; naive; children; HIV;
D O I
10.1046/j.1365-2249.2000.01152.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Previous studies have shown a slow recovery of naive CD4(+) T cell counts after anti-retroviral therapy in HIV-1-infected adults, which is in accordance with thymus atrophy after puberty. Here we investigate whether or not different patterns of naive CD4(+) and CD8(+) T cell repopulation are present in adult and child patients undergoing anti-retroviral treatment. Thus, 25 adults under highly active anti-retroviral therapy and 10 children under combined anti-retroviral therapy were retrospectively analysed for T cell subpopulations at baseline (T0) and around week 12 (T1) and week 24 (T2) of anti-retroviral treatment. Mean serum HIV-1 RNA levels dropped in both groups. Recovery of T cells in adults was characterized by a heterogeneous response between patients, with only 44% of them increasing their naive CD4(+) and CD8(+) T cell counts at T1, and changes in mean total CD4(+) T cells were mainly shaped by memory cells. Otherwise, children were characterized by an early increase in naive T cells. Thus, at T1, all children analysed had a strong rise in CD4(+) (from 389 +/- 116 to 569 +/- 121 cells/mu l; P < 0.01), and nine out of 10 also in naive CD8(+) T cells (from 244 +/- 58 to 473 +/- 85 cells/mu l; P < 0.05). However, no significant correlation between age and naive repopulation was observed (P = 0.22) in children. Thus, children had the earlier and greater increases in naive T cell subsets than adults, probably due to a more active thymus, with the potential for immune reconstitution when HIV-1 replication is controlled.
引用
收藏
页码:493 / 498
页数:6
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