High-titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors

被引：31

作者：

Bayani, N

Rugina, M

Haddad-Vergnes, L

Lelong, F

机构：

[1] Ctr Hosp Intercommunal Creteil, Hematol Lab, F-94010 Creteil, France

[2] Creteil Intercommunal Hosp Ctr, Dept OtoRhino Laryngol & Cervico Facial Surg, Creteil, France

[3] Creteil Intercommunal Hosp Ctr, Dept Oncol, Creteil, France

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2002年 / 71卷 / 01期

关键词：

acquired factor V inhibitor; malignancy; corticosteroids; cyclophosphamide;

D O I：

10.1002/ajh.10172

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 79-year-old man with two simultaneous malignant tumors (buccal epidermoid carcinoma and prostatic adenocarcinoma) who developed a severe bleeding complication at the site of the buccal tumor as well as a massive cerebral hematoma after a skull trauma. Laboratory findings showed the presence of a high-titer specific factor V inhibitor. The patient failed to respond to intravenous immunoglobulins, but both clinical and laboratory improvement was obtained after treatment with corticosteroids and cyclophosphamide. (C) 2002 Wiley-Liss, Inc.

引用

页码：33 / 36

页数：4

共 21 条

[11] Acquired factor V inhibitors [J].