How genetic analysis tests theories of animal aging

被引：47

作者：

Hekimi, Siegfried ^{[1
]}

机构：

[1] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

来源：

NATURE GENETICS | 2006年 / 38卷 / 09期

关键词：

D O I：

10.1038/ng1881

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Each animal species displays a specific life span, rate of aging and pattern of development of age-dependent diseases. The genetic bases of these related features are being studied experimentally in invertebrate and vertebrate model systems as well as in humans through medical records. Three types of mutants are being analyzed: (i) short-lived mutants that are prone to age-dependent diseases and might be models of accelerated aging; (ii) mutants that show overt molecular defects but that do not live shorter lives than controls, and can be used to test specific theories about the molecular causes of aging and age-dependent diseases; and (iii) long-lived mutants that might advance the understanding of the molecular physiology of slow-aging animals and aid the discovery of molecular targets that could be used to manipulate rates of aging to benefit human health. Here, I analyze some of what we know today and discuss what we should try to find out in the future to understand the aging phenomenon.

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页码：985 / 991

页数：7

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