Melatonin regulates energy balance and attenuates fever in Siberian hamsters

被引:55
作者
Bilbo, SD [1 ]
Nelson, RJ
机构
[1] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
[3] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA
关键词
D O I
10.1210/en.143.7.2527
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fever is considered an important host defense response but requires significant metabolic energy. During winter many animals must balance immune function with competing physiological demands (i.e. thermoregulation) to survive. Winter-like patterns of melatonin secretion induce a number of energy-saving adaptations. For instance, Siberian hamsters attenuate the duration of fever during simulated short winter day lengths, presumably to conserve energy. To determine the proximate role of melatonin in mediating this photoperiodic response, hamsters housed in long days were injected with saline or melatonin 4 h before lights off for either 1 or 6 wk and assessed for fever following injections of bacterial lipopolysaccharide. Fever duration was attenuated (32%) only in hamsters that decreased body mass, increased cortisol, and exhibited gonadal regression in response to 6 wk of melatonin. Because melatonin-treated hamsters lost significant body mass, fever was assessed in a second long-day group following ad libitum food intakes food restriction, or 24-h food deprivation. Food restriction sufficient to reduce body mass by approximately 25%, but not to reduce leptin, did not influence fever, and 24-h food deprivation virtually abolished fever. Our data suggest that long-term exposure to long-duration melatonin signals is required to induce the physiological changes necessary for short-day immune responses, perhaps involving interactions with hormones such as cortisol and leptin.
引用
收藏
页码:2527 / 2533
页数:7
相关论文
共 52 条
[1]  
ARDAWI MSM, 1985, ESSAYS BIOCHEM, V21, P1
[2]   CONTROL OF TORPOR AND BODY-WEIGHT PATTERNS BY A SEASONAL TIMER IN SIBERIAN HAMSTERS [J].
BARTNESS, TJ ;
ELLIOTT, JA ;
GOLDMAN, BD .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (01) :R142-R149
[3]   A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis [J].
Ben-Hur, T ;
Cialic, R ;
Itzik, A ;
Barak, O ;
Yirmiya, R ;
Weidenfeld, J .
NEUROSCIENCE, 2001, 108 (01) :119-127
[4]   Neurohormonal host defense in endotoxin shock [J].
Berczi, I .
NEUROIMMUNOMODULATION: MOLECULAR ASPECTS, INTEGRATIVE SYSTEMS, AND CLINICAL ADVANCES, 1998, 840 :787-802
[5]   Short day lengths attenuate the symptoms of infection in Siberian hamsters [J].
Bilbo, SD ;
Drazen, DL ;
Quan, N ;
He, LL ;
Nelson, RJ .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 269 (1490) :447-454
[6]   Short day lengths augment stress-induced leukocyte trafficking and stress-induced enhancement of skin immune function [J].
Bilbo, SD ;
Dhabhar, FS ;
Viswanathan, K ;
Saul, A ;
Yellon, SM ;
Nelson, RJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :4067-4072
[7]   Sex steroid hormones enhance immune function in male and female Siberian hamsters [J].
Bilbo, SD ;
Nelson, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (01) :R207-R213
[8]  
Busser FJM, 1978, J VET PHARMACOL THER, V1, P69
[9]  
CONTI A, 2000, NEUROIMMUNOMODULATIO
[10]   Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin [J].
Cuzzocrea, S ;
Costantino, G ;
Mazzon, E ;
Caputi, AP .
JOURNAL OF PINEAL RESEARCH, 1999, 27 (01) :9-14