The role of Jak3 in lymphoid development, activation, and signaling

被引：70

作者：

Thomis, DC ^{[1
]}

Berg, LJ ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT MOL & CELLULAR BIOL,CAMBRIDGE,MA 02138

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(97)80108-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations in a number of lymphoid signaling molecules lead to immunodeficiencies in mice and humans. Among these, one very pleiotropic syndrome results from deficiencies in an array of cytokine signaling pathways utilizing a cytokine receptor common gamma chain, gamma(c), and the tyrosine kinase Jak3. Recent advances in our understanding of the role of gamma(c) and Jak3 in lymphocyte development and function highlight the importance of cytokine receptor signaling pathways in regulating lymphoid homeostasis and responsiveness.

引用

页码：541 / 547

页数：7

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