Persistently elevated circulating Th22 reversely correlates with prognosis in HBV-related acute-on-chronic liver failure

被引：51

作者：

Mo, Ruidong ^{[1
,2
]}

Wang, Peng ^{[1
,2
]}

Lai, Rongtao ^{[1
,2
]}

Li, Fanlu ^{[1
]}

Liu, Yuhan ^{[1
,2
]}

Jiang, Shaowen ^{[1
,2
]}

Zhao, Gangde ^{[1
]}

Guo, Simin ^{[1
]}

Zhou, Huijuan ^{[1
]}

Lin, Lanyi ^{[1
]}

Lu, Jie ^{[1
,2
]}

Cai, Wei ^{[1
]}

Wang, Hui ^{[1
]}

Yu, Hong ^{[1
]}

Bao, Shisan ^{[1
,2
]}

Xiang, Xiaogang ^{[1
,2
]}

Xie, Qing ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Infect Dis,Translat Lab Liver Dis, Shanghai 200025, Peoples R China

[2] Univ Sydney, Discipline Pathol, New South Wales, Australia

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2017年 / 32卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Th22; Th17; IL-22; CHB; ACLF; HEPATITIS-B-VIRUS; DISEASE PROGRESSION; SKIN INFLAMMATION; IMMUNE-RESPONSE; TH17; CELLS; IL-22; INTERLEUKIN-22; INFECTION; CIRRHOSIS; SEVERITY;

D O I：

10.1111/jgh.13537

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background and Aim: Hepatitis B virus-related acute-on-chronic liver failure (HBVACLF) is an acute deterioration of liver function on chronic liver disease with immune disorder. Th22 cells and IL-22 were correlated with inflammatory and autoimmune diseases. However, Th22 cells and IL-22 in the pathogenesis of HBV-ACLF remains to be elucidated. It was investigated the correlation between Th22 and prognosis in HBVACLF. Methods: Seventy-one HBV-ACLF and 65 chronic hepatitis B patients were recruited. The peripheral frequencies of Th22, Th17 and Th1, or IL-22 and IL-17 were determined, using flow cytometry or ELISA, respectively. It was further analyzed the correlation between Th22 mediated circulating IL-22 and survival rate of HBV-ACLF patients. Results: It was upregulated that the peripheral frequencies of Th22/Th17 cells as well as plasma IL-22 and IL-17 in HBV-ACLF patients, but the frequency of Th1 cells was decreased, compared with health controls. Elevated Th22 cells and IL-22 were correlated with HBV-ACLF disease severity. Elevated plasma IL-22 level (>29.5 pg/ml) was correlated with poor survival rate of HBV-ACLF patients at baseline, using Kaplan-Meier analysis. Conclusions: Persistently elevated circulating Th22 reversely correlates with prognosis in HBV-ACLF. Th22 cells/IL-22 might be served as biomarkers for evaluating the prognosis of HBV-ACLF.

引用

页码：677 / 686

页数：10

共 50 条

[1]

[Anonymous], 2013, ZHONGHUA GAN ZANG BI, V21, P177

[2]

[Anonymous], 2011, ZHONGHUA LIU XING BI, V32, P405

[3]

Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis [J].

Arroyo, Vicente ;

Moreau, Richard ;

Jalan, Rajiv ;

Gines, Pere .

JOURNAL OF HEPATOLOGY, 2015, 62 :S131-S143

[4]

Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria [J].

Basu, Rajatava ;

O'Quinn, Darrell B. ;

Silberger, Daniel J. ;

Schoeb, Trenton R. ;

Fouser, Lynette ;

Ouyang, Wenjun ;

Hatton, Robin D. ;

Weaver, Casey T. .

IMMUNITY, 2012, 37 (06) :1061-1075

[5]

Acute-on-chronic liver failure [J].

Bernal, William ;

Jalan, Rajiv ;

Quaglia, Alberto ;

Simpson, Kenneth ;

Wendon, Julia ;

Burroughs, Andrew .

LANCET, 2015, 386 (10003) :1576-1587

[6]

Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management [J].

Blasco-Algora, Sara ;

Masegosa-Ataz, Jose ;

Gutierrez-Garcia, Maria Luisa ;

Alonso-Lopez, Sonia ;

Fernandez-Rodriguez, Conrado M. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (42) :12125-12140

[7]

A role for T cell-derived interleukin 22 in psoriatic skin inflammation [J].

Boniface, K. ;

Guignouard, E. ;

Pedretti, N. ;

Garcia, M. ;

Delwail, A. ;

Bernard, F. -X. ;

Nau, F. ;

Guillet, G. ;

Dagregorio, G. ;

Yssel, H. ;

Lecron, J. -C. ;

Morel, F. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 150 (03) :407-415

[8]

The Role of IL-22 in Viral Infections: Paradigms and Paradoxes [J].

Brias, Silvia Gimeno ;

Stack, Gabrielle ;

Stacey, Maria A. ;

Redwood, Alec J. ;

Humphreys, Ian R. .

FRONTIERS IN IMMUNOLOGY, 2016, 7

[9]

The need for transparency and good practices in the qPCR literature [J].

Bustin, Stephen A. ;

Benes, Vladimir ;

Garson, Jeremy ;

Hellemans, Jan ;

Huggett, Jim ;

Kubista, Mikael ;

Mueller, Reinhold ;

Nolan, Tania ;

Pfaffl, Michael W. ;

Shipley, Gregory ;

Wittwer, Carl T. ;

Schjerling, Peter ;

Day, Philip J. ;

Abreu, Monica ;

Aguado, Begona ;

Beaulieu, Jean-Francois ;

Beckers, Anneleen ;

Bogaert, Sara ;

Browne, John A. ;

Carrasco-Ramiro, Fernando ;

Ceelen, Liesbeth ;

Ciborowski, Kate ;

Cornillie, Pieter ;

Coulon, Stephanie ;

Cuypers, Ann ;

De Brouwer, Sara ;

De Ceuninck, Leentje ;

De Craene, Jurgen ;

De Naeyer, Helene ;

De Spiegelaere, Ward ;

Deckers, Kato ;

Dheedene, Annelies ;

Durinck, Kaat ;

Ferreira-Teixeira, Margarida ;

Fieuw, Annelies ;

Gallup, Jack M. ;

Gonzalo-Flores, Sandra ;

Goossens, Karen ;

Heindryckx, Femke ;

Herring, Elizabeth ;

Hoenicka, Hans ;

Icardi, Laura ;

Jaggi, Rolf ;

Javad, Farzad ;

Karampelias, Michael ;

Kibenge, Frederick ;

Kibenge, Molly ;

Kumps, Candy ;

Lambertz, Irina ;

Lammens, Tim .

NATURE METHODS, 2013, 10 (11) :1063-1067

[10]

Cai GF, 1999, EUR J IMMUNOL, V29, P2658, DOI 10.1002/(SICI)1521-4141(199909)29:09<2658::AID-IMMU2658>3.0.CO

← 1 2 3 4 5 →