Stereoselective catalytic Tishchenko reduction of β-hydroxyketones using scandium triflate

被引：24

作者：

Gillespie, KM ^{[1
]}

Munslow, IJ ^{[1
]}

Scott, P ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 52期

关键词：

scandium; scandium compounds; reduction; aldols; diastereoselection;

D O I：

10.1016/S0040-4039(99)01986-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of aliphatic and aromatic beta-hydroxyketones were reduced to 1,3-diol monoesters by aldehydes in the presence of a catalytic amount of scandium triflate. Chiral substrates were reduced with high 1,3-anti diastereoselectivity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：9371 / 9374

页数：4

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